Multifactorial risk profile for bone fractures in primary hyperparathyroidism
(2002) In World Journal of Surgery 26(12). p.1463-1467- Abstract
- Primary hyperparathyroidism (pHPT) is associated with an increased fracture risk, and decreased bone density thus has been considered an indication for surgery. However, many pHPT patients have a multifactorial risk profile for osteoporosis and bone fractures. The aim of the present study was to evaluate variables associated with fracture risk within the group of pHPT patients. A series of 203 consecutive patients operated for pHPT were investigated with bone mineral content and biochemical and clinical risk factors for bone fracture. Seventeen patients (8%) had a history of at least one bone fracture up to 5 years before pHPT surgery. Twenty-six patients (13%) had a history of at least one fracture during the 10-year period prior to... (More)
- Primary hyperparathyroidism (pHPT) is associated with an increased fracture risk, and decreased bone density thus has been considered an indication for surgery. However, many pHPT patients have a multifactorial risk profile for osteoporosis and bone fractures. The aim of the present study was to evaluate variables associated with fracture risk within the group of pHPT patients. A series of 203 consecutive patients operated for pHPT were investigated with bone mineral content and biochemical and clinical risk factors for bone fracture. Seventeen patients (8%) had a history of at least one bone fracture up to 5 years before pHPT surgery. Twenty-six patients (13%) had a history of at least one fracture during the 10-year period prior to surgery. In the univariate analyses corticosteroid treatment, serum levels of alkaline phosphatase, 25-hydroxyvitamin D-3, type I collagen telopeptide, and bone mineral content were found to be associated with a history of bone fractures up to 10 years before surgery. Additionally, age and menopausal status were of importance for fractures during the 10-year-period, whereas a history of cardiovascular disease was important for fractures during the 5-year-period prior to surgery. Multivariate analyses showed that serum level of PTH was independently associated with bone fractures during the 5-year period prior to pHPT surgery and further that serum level of 25-hydroxyvitainin D-3 was associated with fractures up to 10 years before surgery. In conclusion, serum levels of 25-hydroxyvitamin D-3 and PTH were independently associated with a history of bone fractures in pHPT. These variables should be considered when evaluating patients for parathyroid surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/321184
- author
- Nordenstrom, E ; Westerdahl, Johan LU ; Lindergård, Birger LU ; Lindblom, Pia LU and Bergenfelz, Anders LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- World Journal of Surgery
- volume
- 26
- issue
- 12
- pages
- 1463 - 1467
- publisher
- Springer
- external identifiers
-
- pmid:12297914
- wos:000179865400012
- scopus:0036886030
- pmid:12297914
- ISSN
- 1432-2323
- DOI
- 10.1007/s00268-002-6433-2
- language
- English
- LU publication?
- yes
- id
- 597728dc-9218-4e73-adf0-740e473ffa7f (old id 321184)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12297914&dopt=Abstract
- date added to LUP
- 2016-04-01 16:41:43
- date last changed
- 2022-03-15 02:17:23
@article{597728dc-9218-4e73-adf0-740e473ffa7f, abstract = {{Primary hyperparathyroidism (pHPT) is associated with an increased fracture risk, and decreased bone density thus has been considered an indication for surgery. However, many pHPT patients have a multifactorial risk profile for osteoporosis and bone fractures. The aim of the present study was to evaluate variables associated with fracture risk within the group of pHPT patients. A series of 203 consecutive patients operated for pHPT were investigated with bone mineral content and biochemical and clinical risk factors for bone fracture. Seventeen patients (8%) had a history of at least one bone fracture up to 5 years before pHPT surgery. Twenty-six patients (13%) had a history of at least one fracture during the 10-year period prior to surgery. In the univariate analyses corticosteroid treatment, serum levels of alkaline phosphatase, 25-hydroxyvitamin D-3, type I collagen telopeptide, and bone mineral content were found to be associated with a history of bone fractures up to 10 years before surgery. Additionally, age and menopausal status were of importance for fractures during the 10-year-period, whereas a history of cardiovascular disease was important for fractures during the 5-year-period prior to surgery. Multivariate analyses showed that serum level of PTH was independently associated with bone fractures during the 5-year period prior to pHPT surgery and further that serum level of 25-hydroxyvitainin D-3 was associated with fractures up to 10 years before surgery. In conclusion, serum levels of 25-hydroxyvitamin D-3 and PTH were independently associated with a history of bone fractures in pHPT. These variables should be considered when evaluating patients for parathyroid surgery.}}, author = {{Nordenstrom, E and Westerdahl, Johan and Lindergård, Birger and Lindblom, Pia and Bergenfelz, Anders}}, issn = {{1432-2323}}, language = {{eng}}, number = {{12}}, pages = {{1463--1467}}, publisher = {{Springer}}, series = {{World Journal of Surgery}}, title = {{Multifactorial risk profile for bone fractures in primary hyperparathyroidism}}, url = {{http://dx.doi.org/10.1007/s00268-002-6433-2}}, doi = {{10.1007/s00268-002-6433-2}}, volume = {{26}}, year = {{2002}}, }