Advanced

Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma

Mineta, H; Miura, K; Takebayashi, S; Misawa, K; Ueda, Y; Suzuki, I; Ito, M and Wennerberg, Johan LU (2003) In Oral Oncology 39(1). p.56-63
Abstract
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcriptase polymerase chain reaction. The association between FHIT expression and clinicopathologic characteristics including p53 and Ki-67 expressions was analyzed. Immunohistochemical analysis revealed 30 patients (53%) of low FHIT expression and 27 patients (47%) of high FHIT expression. Low FHIT expression significantly correlated with high Ki-67... (More)
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcriptase polymerase chain reaction. The association between FHIT expression and clinicopathologic characteristics including p53 and Ki-67 expressions was analyzed. Immunohistochemical analysis revealed 30 patients (53%) of low FHIT expression and 27 patients (47%) of high FHIT expression. Low FHIT expression significantly correlated with high Ki-67 expression, indicating that tumor cells with low FHIT expression can proliferate aggressively. No correlation was found between FHIT expression and clinical characteristics including age, gender, tumor size, lymph node status, stage grouping, histologic grade, p53 expression, and prognosis. FHIT alteration may play an important role in cancer development of HNSCC, however it did not contribute to the prognosis. (C) 2002 Elsevier Science Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunohistochemistry, Ki-67 expression, fragile histidine triad (FHIT) gene, head and neck cancer
in
Oral Oncology
volume
39
issue
1
pages
56 - 63
publisher
Elsevier
external identifiers
  • pmid:12457722
  • wos:000179814200009
  • scopus:0037210505
ISSN
1879-0593
DOI
10.1016/S1368-8375(02)00022-2
language
English
LU publication?
yes
id
7a82c5c6-fa19-45c2-8e3c-640af989d30f (old id 321550)
date added to LUP
2007-09-18 12:40:54
date last changed
2018-05-29 09:18:25
@article{7a82c5c6-fa19-45c2-8e3c-640af989d30f,
  abstract     = {Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcriptase polymerase chain reaction. The association between FHIT expression and clinicopathologic characteristics including p53 and Ki-67 expressions was analyzed. Immunohistochemical analysis revealed 30 patients (53%) of low FHIT expression and 27 patients (47%) of high FHIT expression. Low FHIT expression significantly correlated with high Ki-67 expression, indicating that tumor cells with low FHIT expression can proliferate aggressively. No correlation was found between FHIT expression and clinical characteristics including age, gender, tumor size, lymph node status, stage grouping, histologic grade, p53 expression, and prognosis. FHIT alteration may play an important role in cancer development of HNSCC, however it did not contribute to the prognosis. (C) 2002 Elsevier Science Ltd. All rights reserved.},
  author       = {Mineta, H and Miura, K and Takebayashi, S and Misawa, K and Ueda, Y and Suzuki, I and Ito, M and Wennerberg, Johan},
  issn         = {1879-0593},
  keyword      = {immunohistochemistry,Ki-67 expression,fragile histidine triad (FHIT) gene,head and neck cancer},
  language     = {eng},
  number       = {1},
  pages        = {56--63},
  publisher    = {Elsevier},
  series       = {Oral Oncology},
  title        = {Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma},
  url          = {http://dx.doi.org/10.1016/S1368-8375(02)00022-2},
  volume       = {39},
  year         = {2003},
}