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Levodopa-induced dyskinesia is strongly associated with resonant cortical oscillations.

Halje, Pär LU ; Tamté, Martin LU ; Richter, Ulrike LU ; Mohammed, Mohsin LU ; Cenci Nilsson, Angela LU and Petersson, Per LU (2012) In The Journal of neuroscience : the official journal of the Society for Neuroscience 32(47). p.16541-16551
Abstract
The standard pharmacological treatment for Parkinson's disease using the dopamine precursor levodopa is unfortunately limited by gradual development of disabling involuntary movements for which the underlying causes are poorly understood. Here we show that levodopa-induced dyskinesia in hemiparkinsonian rats is strongly associated with pronounced 80 Hz local field potential oscillations in the primary motor cortex following levodopa treatment. When this oscillation is interrupted by application of a dopamine antagonist onto the cortical surface the dyskinetic symptoms disappear. The finding that abnormal cortical oscillations are a key pathophysiological mechanism calls for a revision of the prevailing hypothesis that links... (More)
The standard pharmacological treatment for Parkinson's disease using the dopamine precursor levodopa is unfortunately limited by gradual development of disabling involuntary movements for which the underlying causes are poorly understood. Here we show that levodopa-induced dyskinesia in hemiparkinsonian rats is strongly associated with pronounced 80 Hz local field potential oscillations in the primary motor cortex following levodopa treatment. When this oscillation is interrupted by application of a dopamine antagonist onto the cortical surface the dyskinetic symptoms disappear. The finding that abnormal cortical oscillations are a key pathophysiological mechanism calls for a revision of the prevailing hypothesis that links levodopa-induced dyskinesia to an altered sensitivity to dopamine only in the striatum. Apart from having important implications for the treatment of Parkinson's disease, the discovered pathophysiological mechanism may also play a role in several other psychiatric and neurological conditions involving cortical dysfunction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of neuroscience : the official journal of the Society for Neuroscience
volume
32
issue
47
pages
16541 - 16551
publisher
Society for Neuroscience
external identifiers
  • wos:000311420800002
  • pmid:23175810
  • scopus:84870047474
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.3047-12.2012
language
English
LU publication?
yes
id
33e91a9e-d3bb-4b8d-a6df-d4b3caddf179 (old id 3218565)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23175810?dopt=Abstract
date added to LUP
2012-12-03 20:56:35
date last changed
2017-11-05 04:12:37
@article{33e91a9e-d3bb-4b8d-a6df-d4b3caddf179,
  abstract     = {The standard pharmacological treatment for Parkinson's disease using the dopamine precursor levodopa is unfortunately limited by gradual development of disabling involuntary movements for which the underlying causes are poorly understood. Here we show that levodopa-induced dyskinesia in hemiparkinsonian rats is strongly associated with pronounced 80 Hz local field potential oscillations in the primary motor cortex following levodopa treatment. When this oscillation is interrupted by application of a dopamine antagonist onto the cortical surface the dyskinetic symptoms disappear. The finding that abnormal cortical oscillations are a key pathophysiological mechanism calls for a revision of the prevailing hypothesis that links levodopa-induced dyskinesia to an altered sensitivity to dopamine only in the striatum. Apart from having important implications for the treatment of Parkinson's disease, the discovered pathophysiological mechanism may also play a role in several other psychiatric and neurological conditions involving cortical dysfunction.},
  author       = {Halje, Pär and Tamté, Martin and Richter, Ulrike and Mohammed, Mohsin and Cenci Nilsson, Angela and Petersson, Per},
  issn         = {1529-2401},
  language     = {eng},
  number       = {47},
  pages        = {16541--16551},
  publisher    = {Society for Neuroscience},
  series       = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  title        = {Levodopa-induced dyskinesia is strongly associated with resonant cortical oscillations.},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.3047-12.2012},
  volume       = {32},
  year         = {2012},
}