Leukocytosis at the onset of diabetes in crosses of inbred BB rats
Eastman, Susan ; Markholst, Helle ; Wilson, Deborah and Lernmark, Åke LU
(1991)
In Diabetes Research and Clinical Practice
12(2).
p.113-123
- Abstract
Inbred lymphopenic, diabetes-prone (DP) and non-lymphopenic, diabetes-resistant (DR) BB rats in a specific pathogen-free (SPF) colony were subjected to a cross-intercross breeding experiment which showed diabetes to segregate as a recessive trait. All DP rats, but none of the DR and F1 rats, developed diabetes. In contrast, about 25% of the F2 rats developed diabetes which made it possible to study these rats without maternal influence of diabetes. All rats were bled at regular intervals between 30 and 150 days of age, and the samples analyzed for numbers of leukocytes, lymphocytes, neutrophils, monocytes and eosinophils. Leukocyte numbers tended to increase with age until about 100 days, and to decline thereafter. Males had more... (More)
Inbred lymphopenic, diabetes-prone (DP) and non-lymphopenic, diabetes-resistant (DR) BB rats in a specific pathogen-free (SPF) colony were subjected to a cross-intercross breeding experiment which showed diabetes to segregate as a recessive trait. All DP rats, but none of the DR and F1 rats, developed diabetes. In contrast, about 25% of the F2 rats developed diabetes which made it possible to study these rats without maternal influence of diabetes. All rats were bled at regular intervals between 30 and 150 days of age, and the samples analyzed for numbers of leukocytes, lymphocytes, neutrophils, monocytes and eosinophils. Leukocyte numbers tended to increase with age until about 100 days, and to decline thereafter. Males had more leukocytes than females. Coinciding with the time of onset of overt diabetes, there was a large increase in eosinophils, along with smaller increases in neutrophils, monocytes and lymphocytes. These data in SPF DP and DR BB rats and their cross-intercross offspring demonstrate that the overt onset of diabetes is associated with a significant leukocytosis.
(Less)
- author
- Eastman, Susan
; Markholst, Helle
; Wilson, Deborah
and Lernmark, Åke
LU
- publishing date
- 1991-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Autoimmunity, Eosinophilia, Insulin-dependent diabetes, Insulitis, Neutrophilia
- in
- Diabetes Research and Clinical Practice
- volume
- 12
- issue
- 2
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0025892542
- pmid:1879302
- ISSN
- 0168-8227
- DOI
- 10.1016/0168-8227(91)90088-U
- language
- English
- LU publication?
- no
- id
- 321eba84-6c7a-44ce-b503-3938bea29a9a
- date added to LUP
- 2019-09-11 09:39:58
- date last changed
- 2024-03-13 08:21:19
@article{321eba84-6c7a-44ce-b503-3938bea29a9a,
abstract = {{<p>Inbred lymphopenic, diabetes-prone (DP) and non-lymphopenic, diabetes-resistant (DR) BB rats in a specific pathogen-free (SPF) colony were subjected to a cross-intercross breeding experiment which showed diabetes to segregate as a recessive trait. All DP rats, but none of the DR and F1 rats, developed diabetes. In contrast, about 25% of the F2 rats developed diabetes which made it possible to study these rats without maternal influence of diabetes. All rats were bled at regular intervals between 30 and 150 days of age, and the samples analyzed for numbers of leukocytes, lymphocytes, neutrophils, monocytes and eosinophils. Leukocyte numbers tended to increase with age until about 100 days, and to decline thereafter. Males had more leukocytes than females. Coinciding with the time of onset of overt diabetes, there was a large increase in eosinophils, along with smaller increases in neutrophils, monocytes and lymphocytes. These data in SPF DP and DR BB rats and their cross-intercross offspring demonstrate that the overt onset of diabetes is associated with a significant leukocytosis.</p>}},
author = {{Eastman, Susan and Markholst, Helle and Wilson, Deborah and Lernmark, Åke}},
issn = {{0168-8227}},
keywords = {{Autoimmunity; Eosinophilia; Insulin-dependent diabetes; Insulitis; Neutrophilia}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{113--123}},
publisher = {{Elsevier}},
series = {{Diabetes Research and Clinical Practice}},
title = {{Leukocytosis at the onset of diabetes in crosses of inbred BB rats}},
url = {{http://dx.doi.org/10.1016/0168-8227(91)90088-U}},
doi = {{10.1016/0168-8227(91)90088-U}},
volume = {{12}},
year = {{1991}},
}