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Evolution and isoform specificity of plant 14-3-3 proteins

Sehnke, PC; Rosenquist, Magnus LU ; Alsterfjord, Magnus LU ; DeLille, J; Sommarin, Marianne LU ; Larsson, Christer LU and Ferl, RJ (2002) In Plant Molecular Biology 50(6). p.1011-1018
Abstract
The 14-3-3 proteins, once thought of as obscure mammalian brain proteins, are fast becoming recognized as major regulators of plant primary metabolism and of other cellular processes. Their presence as large gene families in plants underscores their essential role in plant physiology. We have examined the Arabidopsis thaliana 14-3-3 gene family, which currently is the largest and most complete 14-3-3 family with at least 12 expressed members and 15 genes from the now completed Arabidopsis thaliana genome project. The phylogenetic branching of this family serves as the prototypical model for comparison with other large plant 14-3-3 families and as such may serve to rationalize clustering in a biological context. Equally important for... (More)
The 14-3-3 proteins, once thought of as obscure mammalian brain proteins, are fast becoming recognized as major regulators of plant primary metabolism and of other cellular processes. Their presence as large gene families in plants underscores their essential role in plant physiology. We have examined the Arabidopsis thaliana 14-3-3 gene family, which currently is the largest and most complete 14-3-3 family with at least 12 expressed members and 15 genes from the now completed Arabidopsis thaliana genome project. The phylogenetic branching of this family serves as the prototypical model for comparison with other large plant 14-3-3 families and as such may serve to rationalize clustering in a biological context. Equally important for ascribing common functions for the various 14-3-3 isoforms is determining an isoform-specific correlation with localization and target partnering. A summary of localization information available in the literature is presented. In an effort to identify specific 14-3-3 isoform location and participation in cellular processes, we have produced a panel of isoform-specific antibodies to Arabidopsis thaliana 14-3-3s and present initial immunolocalization studies that suggest biologically relevant, discriminative partnering of 14-3-3 isoforms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Plant Molecular Biology
volume
50
issue
6
pages
1011 - 1018
publisher
Kluwer
external identifiers
  • pmid:12516868
  • wos:000179513300014
  • scopus:0347457072
ISSN
1573-5028
DOI
10.1023/A:1021289127519
language
English
LU publication?
yes
id
fc312057-4345-4f3f-ad7d-90ec0ba322c7 (old id 322148)
date added to LUP
2007-11-13 14:32:09
date last changed
2017-05-21 03:33:36
@article{fc312057-4345-4f3f-ad7d-90ec0ba322c7,
  abstract     = {The 14-3-3 proteins, once thought of as obscure mammalian brain proteins, are fast becoming recognized as major regulators of plant primary metabolism and of other cellular processes. Their presence as large gene families in plants underscores their essential role in plant physiology. We have examined the Arabidopsis thaliana 14-3-3 gene family, which currently is the largest and most complete 14-3-3 family with at least 12 expressed members and 15 genes from the now completed Arabidopsis thaliana genome project. The phylogenetic branching of this family serves as the prototypical model for comparison with other large plant 14-3-3 families and as such may serve to rationalize clustering in a biological context. Equally important for ascribing common functions for the various 14-3-3 isoforms is determining an isoform-specific correlation with localization and target partnering. A summary of localization information available in the literature is presented. In an effort to identify specific 14-3-3 isoform location and participation in cellular processes, we have produced a panel of isoform-specific antibodies to Arabidopsis thaliana 14-3-3s and present initial immunolocalization studies that suggest biologically relevant, discriminative partnering of 14-3-3 isoforms.},
  author       = {Sehnke, PC and Rosenquist, Magnus and Alsterfjord, Magnus and DeLille, J and Sommarin, Marianne and Larsson, Christer and Ferl, RJ},
  issn         = {1573-5028},
  language     = {eng},
  number       = {6},
  pages        = {1011--1018},
  publisher    = {Kluwer},
  series       = {Plant Molecular Biology},
  title        = {Evolution and isoform specificity of plant 14-3-3 proteins},
  url          = {http://dx.doi.org/10.1023/A:1021289127519},
  volume       = {50},
  year         = {2002},
}