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Controlling the microclimate of the skin though the application of occluding films

Sparr, Emma LU ; Millecamp, Danielle; Isoir, Muriel; Burnier, Véronique; Larsson, Åsa LU and Cabane, Bernard (2012) In Journal of the Royal Society Interface
Abstract
The skin barrier is a responding membrane that separates environments with profoundly different

water contents. This implies a substantial water gradient across the skin membrane, which controls

transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as

the activity of water in the outermost layer of skin. By applying an occluding film composed of a

pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to

water evaporation from the body and to increase the microclimate at the skin surface. This way, the

occluding film can be used to increase the skin hydration.

In this study, we develop a... (More)
The skin barrier is a responding membrane that separates environments with profoundly different

water contents. This implies a substantial water gradient across the skin membrane, which controls

transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as

the activity of water in the outermost layer of skin. By applying an occluding film composed of a

pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to

water evaporation from the body and to increase the microclimate at the skin surface. This way, the

occluding film can be used to increase the skin hydration.

In this study, we develop a quantitative method to predict how occluding creams affect skin

hydration. The cosmetic or pharmaceutical product forms a film at the skin surface, which is

described in terms of its specific occlusivity. We present a theoretical model that couples transport

and hydration in responding skin membranes after the application of the film, and an experimental

method to determine the specific occlusivity of films. Finally, we combine the experimental

measures with the theoretical model to obtain a quantitative tool to predict how occluding creams

affect the skin microclimate, the TEWL and the hydration of the upper layer of stratum corneum. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
water transport, specific occlusivity, responding membrane, model emulsions, permeability, hydration
in
Journal of the Royal Society Interface
publisher
Royal Society
ISSN
1742-5662
language
English
LU publication?
yes
id
5996ee9b-90f1-4ca1-9f98-e9ad95d86411 (old id 3222664)
date added to LUP
2012-12-05 09:52:13
date last changed
2016-04-15 17:01:49
@article{5996ee9b-90f1-4ca1-9f98-e9ad95d86411,
  abstract     = {The skin barrier is a responding membrane that separates environments with profoundly different<br/><br>
water contents. This implies a substantial water gradient across the skin membrane, which controls<br/><br>
transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as<br/><br>
the activity of water in the outermost layer of skin. By applying an occluding film composed of a<br/><br>
pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to<br/><br>
water evaporation from the body and to increase the microclimate at the skin surface. This way, the<br/><br>
occluding film can be used to increase the skin hydration.<br/><br>
In this study, we develop a quantitative method to predict how occluding creams affect skin<br/><br>
hydration. The cosmetic or pharmaceutical product forms a film at the skin surface, which is<br/><br>
described in terms of its specific occlusivity. We present a theoretical model that couples transport<br/><br>
and hydration in responding skin membranes after the application of the film, and an experimental<br/><br>
method to determine the specific occlusivity of films. Finally, we combine the experimental<br/><br>
measures with the theoretical model to obtain a quantitative tool to predict how occluding creams<br/><br>
affect the skin microclimate, the TEWL and the hydration of the upper layer of stratum corneum.},
  author       = {Sparr, Emma and Millecamp, Danielle and Isoir, Muriel and Burnier, Véronique and Larsson, Åsa and Cabane, Bernard},
  issn         = {1742-5662},
  keyword      = {water transport,specific occlusivity,responding membrane,model emulsions,permeability,hydration},
  language     = {eng},
  publisher    = {Royal Society},
  series       = {Journal of the Royal Society Interface},
  title        = {Controlling the microclimate of the skin though the application of occluding films},
  year         = {2012},
}