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Lipid phase behaviour under steady state conditions

Åberg, Christoffer LU ; Sparr, Emma LU and Wennerström, Håkan LU (2012) In Faraday Discussions
Abstract
At the interface between two regions, for example the air–liquid interface of a lipid solution, there can arise non-equilibrium situations. The water chemical potential corresponding to the ambient RH will, in general, not match the water chemical potential of the solution, and the gradients in chemical potential cause diffusional flows. If the bulk water chemical potential is close to a phase transition, there is the possibility of forming an interfacial phase with structures qualitatively different from those found in the bulk. Based on a previous analysis of this phenomenon in two component systems (C. Åberg, E. Sparr, K. J. Edler and H. Wennerström, Langmuir, 2009, 25, 12177), we here analyse the phenomenon for three-component systems.... (More)
At the interface between two regions, for example the air–liquid interface of a lipid solution, there can arise non-equilibrium situations. The water chemical potential corresponding to the ambient RH will, in general, not match the water chemical potential of the solution, and the gradients in chemical potential cause diffusional flows. If the bulk water chemical potential is close to a phase transition, there is the possibility of forming an interfacial phase with structures qualitatively different from those found in the bulk. Based on a previous analysis of this phenomenon in two component systems (C. Åberg, E. Sparr, K. J. Edler and H. Wennerström, Langmuir, 2009, 25, 12177), we here analyse the phenomenon for three-component systems. The relevant transport equations are derived, and explicit results are given for some limiting cases. Then the formalism is applied conceptually to four different aqueous lipid systems, which in addition to water and a phospholipid contain (i) octyl glucoside, (ii) urea, (iii) heavy water, and (iv) sodium cholate as the third component. These four cases are chosen to illustrate (i) a method to use a micelle former to transport lipid to the interface where a multi-lamellar structure can form; (ii) to use a co-solvent to inhibit the formation of a gel phase at the interface; (iii) a method to form pure phospholipid multi-lamellar structures at the interface; (iv) a method to form a sequence of phases in the interfacial region. These four cases all have the character of theoretically based conjectures and it remains to investigate experimentally whether or not the conditions can be realized in practice. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Faraday Discussions
publisher
Royal Society of Chemistry
external identifiers
  • wos:000313970200009
  • pmid:23805741
  • scopus:84883026755
ISSN
1364-5498
DOI
10.1039/c2fd20079a
language
English
LU publication?
yes
id
77451351-9eab-495e-9495-3c5fa4a1bc67 (old id 3222686)
date added to LUP
2012-12-05 11:13:13
date last changed
2017-10-08 03:06:17
@article{77451351-9eab-495e-9495-3c5fa4a1bc67,
  abstract     = {At the interface between two regions, for example the air–liquid interface of a lipid solution, there can arise non-equilibrium situations. The water chemical potential corresponding to the ambient RH will, in general, not match the water chemical potential of the solution, and the gradients in chemical potential cause diffusional flows. If the bulk water chemical potential is close to a phase transition, there is the possibility of forming an interfacial phase with structures qualitatively different from those found in the bulk. Based on a previous analysis of this phenomenon in two component systems (C. Åberg, E. Sparr, K. J. Edler and H. Wennerström, Langmuir, 2009, 25, 12177), we here analyse the phenomenon for three-component systems. The relevant transport equations are derived, and explicit results are given for some limiting cases. Then the formalism is applied conceptually to four different aqueous lipid systems, which in addition to water and a phospholipid contain (i) octyl glucoside, (ii) urea, (iii) heavy water, and (iv) sodium cholate as the third component. These four cases are chosen to illustrate (i) a method to use a micelle former to transport lipid to the interface where a multi-lamellar structure can form; (ii) to use a co-solvent to inhibit the formation of a gel phase at the interface; (iii) a method to form pure phospholipid multi-lamellar structures at the interface; (iv) a method to form a sequence of phases in the interfacial region. These four cases all have the character of theoretically based conjectures and it remains to investigate experimentally whether or not the conditions can be realized in practice.},
  author       = {Åberg, Christoffer and Sparr, Emma and Wennerström, Håkan},
  issn         = {1364-5498},
  language     = {eng},
  month        = {06},
  publisher    = {Royal Society of Chemistry},
  series       = {Faraday Discussions},
  title        = {Lipid phase behaviour under steady state conditions},
  url          = {http://dx.doi.org/10.1039/c2fd20079a},
  year         = {2012},
}