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Bandpass Filtering of DNA Elastic Modes Using Confinement and Tension

Lin, Jun; Persson, Fredrik; Fritzsche, Joachim; Tegenfeldt, Jonas LU and Saleh, Omar A. (2012) In Biophysical Journal 102. p.96-100
Abstract
During a variety of biological and technological processes, biopolymers are simultaneously subject to both confinement and external forces. Although significant efforts have gone into understanding the physics of polymers that are only confined, or only under tension, little work has been done to explore the effects of the interplay of force and confinement. Here, we study the combined effects of stretching and confinement on a polymer’s configurational freedom. We measure the elastic response of long double-stranded DNA molecules that are partially confined to thin, nanofabricated slits. We account for the data through a model in which the DNA’s short-wavelength transverse elastic modes are cut off by applied force and the DNA’s bending... (More)
During a variety of biological and technological processes, biopolymers are simultaneously subject to both confinement and external forces. Although significant efforts have gone into understanding the physics of polymers that are only confined, or only under tension, little work has been done to explore the effects of the interplay of force and confinement. Here, we study the combined effects of stretching and confinement on a polymer’s configurational freedom. We measure the elastic response of long double-stranded DNA molecules that are partially confined to thin, nanofabricated slits. We account for the data through a model in which the DNA’s short-wavelength transverse elastic modes are cut off by applied force and the DNA’s bending stiffness, whereas long-wavelength modes are cut off by confinement. Thus, we show that confinement and stretching combine to permit tunable bandpass filtering of the elastic modes of long polymers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biophysical Journal
volume
102
pages
96 - 100
publisher
Cell Press
external identifiers
  • wos:000298825400012
  • scopus:84855443364
ISSN
1542-0086
DOI
10.1016/j.bpj.2011.11.4014
language
English
LU publication?
yes
id
2a34d629-c97f-4fe7-b136-e4b3ee4ec75c (old id 3224893)
date added to LUP
2012-12-14 19:49:15
date last changed
2017-01-01 03:22:02
@article{2a34d629-c97f-4fe7-b136-e4b3ee4ec75c,
  abstract     = {During a variety of biological and technological processes, biopolymers are simultaneously subject to both confinement and external forces. Although significant efforts have gone into understanding the physics of polymers that are only confined, or only under tension, little work has been done to explore the effects of the interplay of force and confinement. Here, we study the combined effects of stretching and confinement on a polymer’s configurational freedom. We measure the elastic response of long double-stranded DNA molecules that are partially confined to thin, nanofabricated slits. We account for the data through a model in which the DNA’s short-wavelength transverse elastic modes are cut off by applied force and the DNA’s bending stiffness, whereas long-wavelength modes are cut off by confinement. Thus, we show that confinement and stretching combine to permit tunable bandpass filtering of the elastic modes of long polymers.},
  author       = {Lin, Jun and Persson, Fredrik and Fritzsche, Joachim and Tegenfeldt, Jonas and Saleh, Omar A.},
  issn         = {1542-0086},
  language     = {eng},
  pages        = {96--100},
  publisher    = {Cell Press},
  series       = {Biophysical Journal},
  title        = {Bandpass Filtering of DNA Elastic Modes Using Confinement and Tension},
  url          = {http://dx.doi.org/10.1016/j.bpj.2011.11.4014},
  volume       = {102},
  year         = {2012},
}