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WE-14, a chromogranin A - Derived neuropeptide

Curry, WJ ; Barkatullah, SC ; Johansson, AN ; Quinn, JG ; Norlén, Per LU ; Connolly, CK ; McCollum, AP and McVicar, CM (2002) In Annals of the New York Academy of Sciences 971. p.311-316
Abstract
The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have... (More)
The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have demonstrated that WE-14 exhibits an ancient lineage, while ontogenetic examination has shown that it is generated at an early stage during fetal development. Putative WE-14 receptor binding sites have been identified in several tissues; however, the physiological role of WE-14 remains enigmatic. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
WE-14, chromogranin A
in
Annals of the New York Academy of Sciences
volume
971
pages
311 - 316
publisher
Wiley-Blackwell
external identifiers
  • wos:000179509100060
  • pmid:12438141
  • scopus:0037024629
ISSN
0077-8923
language
English
LU publication?
yes
id
2595ecce-f7ba-4d5d-91c4-38d1ab172c07 (old id 322676)
alternative location
http://www.annalsnyas.org/cgi/content/abstract/971/1/311
date added to LUP
2016-04-01 16:09:12
date last changed
2022-01-28 17:39:10
@article{2595ecce-f7ba-4d5d-91c4-38d1ab172c07,
  abstract     = {{The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have demonstrated that WE-14 exhibits an ancient lineage, while ontogenetic examination has shown that it is generated at an early stage during fetal development. Putative WE-14 receptor binding sites have been identified in several tissues; however, the physiological role of WE-14 remains enigmatic.}},
  author       = {{Curry, WJ and Barkatullah, SC and Johansson, AN and Quinn, JG and Norlén, Per and Connolly, CK and McCollum, AP and McVicar, CM}},
  issn         = {{0077-8923}},
  keywords     = {{WE-14; chromogranin A}},
  language     = {{eng}},
  pages        = {{311--316}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Annals of the New York Academy of Sciences}},
  title        = {{WE-14, a chromogranin A - Derived neuropeptide}},
  url          = {{http://www.annalsnyas.org/cgi/content/abstract/971/1/311}},
  volume       = {{971}},
  year         = {{2002}},
}