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WE-14, a chromogranin A - Derived neuropeptide

Curry, WJ; Barkatullah, SC; Johansson, AN; Quinn, JG; Norlén, Per LU ; Connolly, CK; McCollum, AP and McVicar, CM (2002) In Annals of the New York Academy of Sciences 971. p.311-316
Abstract
The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have... (More)
The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have demonstrated that WE-14 exhibits an ancient lineage, while ontogenetic examination has shown that it is generated at an early stage during fetal development. Putative WE-14 receptor binding sites have been identified in several tissues; however, the physiological role of WE-14 remains enigmatic. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
WE-14, chromogranin A
in
Annals of the New York Academy of Sciences
volume
971
pages
311 - 316
publisher
New York Academy of Sciences
external identifiers
  • wos:000179509100060
  • pmid:12438141
  • scopus:0037024629
ISSN
0077-8923
language
English
LU publication?
yes
id
2595ecce-f7ba-4d5d-91c4-38d1ab172c07 (old id 322676)
alternative location
http://www.annalsnyas.org/cgi/content/abstract/971/1/311
date added to LUP
2007-08-15 12:26:01
date last changed
2017-06-25 04:23:11
@article{2595ecce-f7ba-4d5d-91c4-38d1ab172c07,
  abstract     = {The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-14 in the adrenal chromaffin cell population and in the enterochromaffin-like (ECL) cells of the oxyntic mucosa. Pathological analyses of neuroendocrine tumors have revealed a heterogeneous pattern of WE-14 immunostaining, with variable concentrations quantified and chromatographically resolved in tissue extracts. Phylogenetic surveys have demonstrated that WE-14 exhibits an ancient lineage, while ontogenetic examination has shown that it is generated at an early stage during fetal development. Putative WE-14 receptor binding sites have been identified in several tissues; however, the physiological role of WE-14 remains enigmatic.},
  author       = {Curry, WJ and Barkatullah, SC and Johansson, AN and Quinn, JG and Norlén, Per and Connolly, CK and McCollum, AP and McVicar, CM},
  issn         = {0077-8923},
  keyword      = {WE-14,chromogranin A},
  language     = {eng},
  pages        = {311--316},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {WE-14, a chromogranin A - Derived neuropeptide},
  volume       = {971},
  year         = {2002},
}