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Serum concentrations of human chorionic gonadotropin beta and its association with survival in patients with colorectal cancer

Birgisson, Helgi; Jirström, Karin LU and Stenman, Ulf-Hakan (2012) In Cancer Biomarkers 11(4). p.173-181
Abstract
Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74;... (More)
Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74; P = 0.004), and this association was stronger in women (P = 0.022) than in men (P = 0.061). In multivariate analyses including age, disease stage, tumour differentiation, vascular invasion and CEA, high serum hCG beta concentrations remained an independent prognostic factor for adverse OS in women (HR 2.26; 95% CI 1.39-3.67), but not in men (HR 0.78; 95% CI 0.41-1.51). The same trend was observed for disease free-and cancer specific survival. High serum concentration of hCG beta is an independent prognostic factor for adverse outcome in women with colorectal cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cancer, colorectal, human chorionic gonadotropin beta, hCG, prognosis, survival
in
Cancer Biomarkers
volume
11
issue
4
pages
173 - 181
publisher
IOS Press
external identifiers
  • wos:000310980000006
  • scopus:84871582252
ISSN
1875-8592
DOI
10.3233/CBM-2012-00279
language
English
LU publication?
yes
id
9b3deb3d-47e9-49a6-a1e3-ff5f248341f3 (old id 3256195)
date added to LUP
2013-01-07 09:36:44
date last changed
2017-01-01 03:15:59
@article{9b3deb3d-47e9-49a6-a1e3-ff5f248341f3,
  abstract     = {Increased serum concentrations of the beta subunit of human chorionic gonadotropin (hCG beta) are associated with adverse prognosis in several cancers. The aim of the present study was to analyse the association between serum hCG beta recurrence, and survival, in patients with colorectal cancer. The concentrations of hCG beta were determined in serum collected preoperatively from 324 patients with colorectal cancer, of whom 270 were curatively treated. The serum concentrations of hCG beta were associated with increasing age and they were higher in women than in men. Using the 75th percentile (1.55 pmol/L) as a cut-off for serum hCG beta, overall survival (OS) was shorter in patients with elevated concentrations (HR 1.95; 95% CI 1.39-2.74; P = 0.004), and this association was stronger in women (P = 0.022) than in men (P = 0.061). In multivariate analyses including age, disease stage, tumour differentiation, vascular invasion and CEA, high serum hCG beta concentrations remained an independent prognostic factor for adverse OS in women (HR 2.26; 95% CI 1.39-3.67), but not in men (HR 0.78; 95% CI 0.41-1.51). The same trend was observed for disease free-and cancer specific survival. High serum concentration of hCG beta is an independent prognostic factor for adverse outcome in women with colorectal cancer.},
  author       = {Birgisson, Helgi and Jirström, Karin and Stenman, Ulf-Hakan},
  issn         = {1875-8592},
  keyword      = {Cancer,colorectal,human chorionic gonadotropin beta,hCG,prognosis,survival},
  language     = {eng},
  number       = {4},
  pages        = {173--181},
  publisher    = {IOS Press},
  series       = {Cancer Biomarkers},
  title        = {Serum concentrations of human chorionic gonadotropin beta and its association with survival in patients with colorectal cancer},
  url          = {http://dx.doi.org/10.3233/CBM-2012-00279},
  volume       = {11},
  year         = {2012},
}