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Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned Na-23/H-1 resonator systems

Wetterling, Friedrich; Ansar, Saema LU and Handwerker, Eva (2012) In Physics in Medicine and Biology 57(21). p.6929-6946
Abstract
A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar... (More)
A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned H-1/Na-23 birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear Na-23/H-1 MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high Na-23 at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear Na-23/H-1 MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
57
issue
21
pages
6929 - 6946
publisher
IOP Publishing
external identifiers
  • wos:000310528700016
  • scopus:84868024301
ISSN
1361-6560
DOI
10.1088/0031-9155/57/21/6929
language
English
LU publication?
yes
id
440b4026-d694-4ab5-b0e9-91797076168b (old id 3256367)
date added to LUP
2013-01-07 09:37:56
date last changed
2017-01-01 04:03:11
@article{440b4026-d694-4ab5-b0e9-91797076168b,
  abstract     = {A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned H-1/Na-23 birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear Na-23/H-1 MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high Na-23 at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear Na-23/H-1 MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue.},
  author       = {Wetterling, Friedrich and Ansar, Saema and Handwerker, Eva},
  issn         = {1361-6560},
  language     = {eng},
  number       = {21},
  pages        = {6929--6946},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned Na-23/H-1 resonator systems},
  url          = {http://dx.doi.org/10.1088/0031-9155/57/21/6929},
  volume       = {57},
  year         = {2012},
}