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Main targets of tetraaza macrocyclic copper complex on L1210 murine leukemia cells

Dovinova, Ima LU ; Paulikova, H; Rauko, P; Hunakova, L'; Hanusovska, E and Tibenska, E (2002) In Toxicology in Vitro 16(5). p.491-498
Abstract
Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002... (More)
Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002 Elsevier Science Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glutathione, stress, oxidative, apoptosis, membrane integrity, copper complex, cytotoxicity
in
Toxicology in Vitro
volume
16
issue
5
pages
491 - 498
publisher
Elsevier
external identifiers
  • pmid:12206815
  • wos:000178436200002
  • scopus:0036801574
ISSN
1879-3177
DOI
10.1016/S0887-2333(02)00043-7
language
English
LU publication?
yes
id
31135caa-49b6-4847-820f-ef1caa40c0fe (old id 325835)
date added to LUP
2007-08-16 10:18:57
date last changed
2017-01-01 06:59:49
@article{31135caa-49b6-4847-820f-ef1caa40c0fe,
  abstract     = {Several metal complex agents have already been introduced into clinical tumor therapy and others are subject of antitumor studies. In this study we focused on the tetraaza macrocyclic copper complex (Cu(TAAB)Cl-2). We studied the influence of the substance on cell growth, cell cycle, membrane integrity, necrosis, apotosis and glutathione level on the leukemic cell line L1210 in 1-day (22 h) and 3-day (72 h) experiments. The metal complex shows a dose-dependent antiproliferative effect, without affecting cell cycle phases. The present results confirm that copper complex can damage plasmatic membranes and trigger apoptosis, and that after treatment of leukemic cells with the copper complex, glutathione levels were increased. (C) 2002 Elsevier Science Ltd. All rights reserved.},
  author       = {Dovinova, Ima and Paulikova, H and Rauko, P and Hunakova, L' and Hanusovska, E and Tibenska, E},
  issn         = {1879-3177},
  keyword      = {glutathione,stress,oxidative,apoptosis,membrane integrity,copper complex,cytotoxicity},
  language     = {eng},
  number       = {5},
  pages        = {491--498},
  publisher    = {Elsevier},
  series       = {Toxicology in Vitro},
  title        = {Main targets of tetraaza macrocyclic copper complex on L1210 murine leukemia cells},
  url          = {http://dx.doi.org/10.1016/S0887-2333(02)00043-7},
  volume       = {16},
  year         = {2002},
}