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Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis

Sanchez, D ; Martinez, S ; Lindqvist, A ; Åkerström, Bo LU and Falkenberg, Cecilia LU (2002) In Mechanisms of Development 117(1-2). p.293-298
Abstract
The expression pattern of the alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle,... (More)
The expression pattern of the alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle, nervous system microvasculature, and connective tissue. Both proteins were found in brain mesenchyme and meninges. Thus, a restricted expression of the AMBP mRNA in a few organs contrasts to a widespread and unique distribution of each of the two proteins. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myocyte, embryogenesis, bikunin, alpha(1)-microglobulin, lipocalin, meninges, cephalic, mesenchyme, liver, chondroblast, pancreas, kidney
in
Mechanisms of Development
volume
117
issue
1-2
pages
293 - 298
publisher
Elsevier
external identifiers
  • pmid:12204273
  • wos:000178268200028
  • scopus:0036768106
ISSN
0925-4773
DOI
10.1016/S0925-4773(02)00202-2
language
English
LU publication?
yes
id
f5be7e35-f074-4cd6-8ad4-a90eb59e45d0 (old id 325998)
date added to LUP
2016-04-01 11:40:54
date last changed
2022-01-26 08:39:20
@article{f5be7e35-f074-4cd6-8ad4-a90eb59e45d0,
  abstract     = {{The expression pattern of the alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle, nervous system microvasculature, and connective tissue. Both proteins were found in brain mesenchyme and meninges. Thus, a restricted expression of the AMBP mRNA in a few organs contrasts to a widespread and unique distribution of each of the two proteins.}},
  author       = {{Sanchez, D and Martinez, S and Lindqvist, A and Åkerström, Bo and Falkenberg, Cecilia}},
  issn         = {{0925-4773}},
  keywords     = {{myocyte; embryogenesis; bikunin; alpha(1)-microglobulin; lipocalin; meninges; cephalic; mesenchyme; liver; chondroblast; pancreas; kidney}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{293--298}},
  publisher    = {{Elsevier}},
  series       = {{Mechanisms of Development}},
  title        = {{Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis}},
  url          = {{http://dx.doi.org/10.1016/S0925-4773(02)00202-2}},
  doi          = {{10.1016/S0925-4773(02)00202-2}},
  volume       = {{117}},
  year         = {{2002}},
}