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Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers

Wesslén, Bengt LU ; Kober, Maria; Freij-Larsson, Christina; Ljungh, Åsa LU and Paulsson, Marianne (1994) In Biomaterials 15(4). p.278-284
Abstract
A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to... (More)
A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
amphiphilic polymers, surface modification, Protein adsorption, polymer grafting, poly(ethylene glycol), polyurethane
in
Biomaterials
volume
15
issue
4
pages
278 - 284
publisher
Elsevier
external identifiers
  • scopus:0028198559
ISSN
1878-5905
DOI
10.1016/0142-9612(94)90052-3
language
English
LU publication?
yes
id
2b614bb4-abba-432f-b063-34ed09c47151 (old id 32616)
date added to LUP
2007-06-15 11:48:49
date last changed
2017-08-20 03:39:08
@article{2b614bb4-abba-432f-b063-34ed09c47151,
  abstract     = {A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones.},
  author       = {Wesslén, Bengt and Kober, Maria and Freij-Larsson, Christina and Ljungh, Åsa and Paulsson, Marianne},
  issn         = {1878-5905},
  keyword      = {amphiphilic polymers,surface modification,Protein adsorption,polymer grafting,poly(ethylene glycol),polyurethane},
  language     = {eng},
  number       = {4},
  pages        = {278--284},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers},
  url          = {http://dx.doi.org/10.1016/0142-9612(94)90052-3},
  volume       = {15},
  year         = {1994},
}