Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers
(1994) In Biomaterials 15(4). p.278-284- Abstract
- A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to... (More)
- A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/32616
- author
- Wesslén, Bengt LU ; Kober, Maria ; Freij-Larsson, Christina ; Ljungh, Åsa LU and Paulsson, Marianne
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- amphiphilic polymers, surface modification, Protein adsorption, polymer grafting, poly(ethylene glycol), polyurethane
- in
- Biomaterials
- volume
- 15
- issue
- 4
- pages
- 278 - 284
- publisher
- Elsevier
- external identifiers
-
- scopus:0028198559
- ISSN
- 1878-5905
- DOI
- 10.1016/0142-9612(94)90052-3
- language
- English
- LU publication?
- yes
- id
- 2b614bb4-abba-432f-b063-34ed09c47151 (old id 32616)
- date added to LUP
- 2016-04-01 12:07:48
- date last changed
- 2021-01-03 03:45:43
@article{2b614bb4-abba-432f-b063-34ed09c47151, abstract = {{A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones.}}, author = {{Wesslén, Bengt and Kober, Maria and Freij-Larsson, Christina and Ljungh, Åsa and Paulsson, Marianne}}, issn = {{1878-5905}}, keywords = {{amphiphilic polymers; surface modification; Protein adsorption; polymer grafting; poly(ethylene glycol); polyurethane}}, language = {{eng}}, number = {{4}}, pages = {{278--284}}, publisher = {{Elsevier}}, series = {{Biomaterials}}, title = {{Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers}}, url = {{http://dx.doi.org/10.1016/0142-9612(94)90052-3}}, doi = {{10.1016/0142-9612(94)90052-3}}, volume = {{15}}, year = {{1994}}, }