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Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Schleede, Simone; Meinel, Felix G.; Bech, Martin LU ; Herzen, Julia; Achterhold, Klaus; Potdevin, Guillaume; Malecki, Andreas; Adam-Neumair, Silvia; Thieme, Sven F. and Bamberg, Fabian, et al. (2012) In Proceedings of the National Academy of Sciences 109(44). p.17880-17885
Abstract
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs.... (More)
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs. (Less)
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publication status
published
subject
keywords
grating interferometer, pulmonary emphysema, X-ray imaging
in
Proceedings of the National Academy of Sciences
volume
109
issue
44
pages
17880 - 17885
publisher
National Acad Sciences
external identifiers
  • wos:000311149900046
  • scopus:84868152432
ISSN
1091-6490
DOI
10.1073/pnas.1206684109
language
English
LU publication?
yes
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23bafbbe-c8f3-4372-bcfa-d22bee21125c (old id 3262722)
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2013-01-07 09:39:20
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2017-11-19 03:14:33
@article{23bafbbe-c8f3-4372-bcfa-d22bee21125c,
  abstract     = {In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.},
  author       = {Schleede, Simone and Meinel, Felix G. and Bech, Martin and Herzen, Julia and Achterhold, Klaus and Potdevin, Guillaume and Malecki, Andreas and Adam-Neumair, Silvia and Thieme, Sven F. and Bamberg, Fabian and Nikolaou, Konstantin and Bohla, Alexander and Yildirim, Ali Oe. and Loewen, Roderick and Gifford, Martin and Ruth, Ronald and Eickelberg, Oliver and Reiser, Maximilian and Pfeiffer, Franz},
  issn         = {1091-6490},
  keyword      = {grating interferometer,pulmonary emphysema,X-ray imaging},
  language     = {eng},
  number       = {44},
  pages        = {17880--17885},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source},
  url          = {http://dx.doi.org/10.1073/pnas.1206684109},
  volume       = {109},
  year         = {2012},
}