Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
(2012) In Proceedings of the National Academy of Sciences 109(44). p.17880-17885- Abstract
- In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs.... (More)
- In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs. (Less)
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https://lup.lub.lu.se/record/3262722
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- grating interferometer, pulmonary emphysema, X-ray imaging
- in
- Proceedings of the National Academy of Sciences
- volume
- 109
- issue
- 44
- pages
- 17880 - 17885
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000311149900046
- scopus:84868152432
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1206684109
- language
- English
- LU publication?
- yes
- id
- 23bafbbe-c8f3-4372-bcfa-d22bee21125c (old id 3262722)
- date added to LUP
- 2016-04-01 10:40:37
- date last changed
- 2022-04-04 20:11:13
@article{23bafbbe-c8f3-4372-bcfa-d22bee21125c, abstract = {{In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.}}, author = {{Schleede, Simone and Meinel, Felix G. and Bech, Martin and Herzen, Julia and Achterhold, Klaus and Potdevin, Guillaume and Malecki, Andreas and Adam-Neumair, Silvia and Thieme, Sven F. and Bamberg, Fabian and Nikolaou, Konstantin and Bohla, Alexander and Yildirim, Ali Oe. and Loewen, Roderick and Gifford, Martin and Ruth, Ronald and Eickelberg, Oliver and Reiser, Maximilian and Pfeiffer, Franz}}, issn = {{1091-6490}}, keywords = {{grating interferometer; pulmonary emphysema; X-ray imaging}}, language = {{eng}}, number = {{44}}, pages = {{17880--17885}}, publisher = {{National Academy of Sciences}}, series = {{Proceedings of the National Academy of Sciences}}, title = {{Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source}}, url = {{http://dx.doi.org/10.1073/pnas.1206684109}}, doi = {{10.1073/pnas.1206684109}}, volume = {{109}}, year = {{2012}}, }