International consensus on antineutrophil cytoplasm antibodies testing in eosinophilic granulomatosis with polyangiitis
(2020) In American Journal of Respiratory and Critical Care Medicine 202(10). p.1360-1372- Abstract
An international consensus on antineutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosiswith polyangiitis (EGPA) is presented.ANCA, specific formyeloperoxidase (MPO), can be detected in 30-35% of patients with EGPA. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms; purpura; polyneuropathy; unexplained heart, gastrointestinal, or kidney disease; and/or pulmonary infiltrates or hemorrhage.Apositive MPO-ANCA result contributes to the diagnostic workup for EGPA. Patients with MPO-ANCA-associated EGPA have vasculitis features, such as glomerulonephritis, neuropathy, and skin manifestations, more... (More)
An international consensus on antineutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosiswith polyangiitis (EGPA) is presented.ANCA, specific formyeloperoxidase (MPO), can be detected in 30-35% of patients with EGPA. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms; purpura; polyneuropathy; unexplained heart, gastrointestinal, or kidney disease; and/or pulmonary infiltrates or hemorrhage.Apositive MPO-ANCA result contributes to the diagnostic workup for EGPA. Patients with MPO-ANCA-associated EGPA have vasculitis features, such as glomerulonephritis, neuropathy, and skin manifestations, more frequently than patients with ANCA-negative EGPA. However, the presence of MPO-ANCA is neither sensitive nor specific enough to identifywhether a patient should be subclassified as having "vasculitic"or "eosinophilic"EGPA. At present, ANCA status cannot guide treatment decisions, that is,whether cyclophosphamide, rituximab, ormepolizumab should be added to conventional glucocorticoid treatment. In EGPA, monitoring of ANCA is only useful when MPO-ANCA was tested positive at disease onset.
(Less)
- author
- Moiseev, Sergey
; Bossuyt, Xavier
; Arimura, Yoshihiro
; Blockmans, Daniel
; Csernok, Elena
; Damoiseaux, Jan
; Emmi, Giacomo
; Flores-Suarez, Luis Felipe
; Hellmich, Bernhard
; Jayne, David
; Charles Jennette, J.
; Little, Mark A.
; Mohammad, Aladdin J.
LU
; Moosig, Frank
; Novikov, Pavel
; Pagnoux, Christian
; Radice, Antonella
; Sada, Ken Ei
; Segelmark, Marten
LU
; Shoenfeld, Yehuda
; Sinico, Renato A.
; Specks, Ulrich
; Terrier, Benjamin
; Tzioufas, Athanasios G.
; Vaglio, Augusto
; Zhao, Ming Hui
and Tervaert, Jan Willem Cohen
(Less) - organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ANCA, Consensus, Eosinophilic granulomatosis with polyangiitis, Vasculitis
- in
- American Journal of Respiratory and Critical Care Medicine
- volume
- 202
- issue
- 10
- pages
- 13 pages
- publisher
- American Thoracic Society
- external identifiers
-
- pmid:32584187
- scopus:85096985242
- ISSN
- 1073-449X
- DOI
- 10.1164/rccm.202005-1628SO
- language
- English
- LU publication?
- yes
- id
- 327239ce-1884-40f3-a1a9-20868bd17a92
- date added to LUP
- 2020-12-11 10:52:39
- date last changed
- 2025-04-18 07:57:21
@article{327239ce-1884-40f3-a1a9-20868bd17a92,
abstract = {{<p>An international consensus on antineutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosiswith polyangiitis (EGPA) is presented.ANCA, specific formyeloperoxidase (MPO), can be detected in 30-35% of patients with EGPA. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms; purpura; polyneuropathy; unexplained heart, gastrointestinal, or kidney disease; and/or pulmonary infiltrates or hemorrhage.Apositive MPO-ANCA result contributes to the diagnostic workup for EGPA. Patients with MPO-ANCA-associated EGPA have vasculitis features, such as glomerulonephritis, neuropathy, and skin manifestations, more frequently than patients with ANCA-negative EGPA. However, the presence of MPO-ANCA is neither sensitive nor specific enough to identifywhether a patient should be subclassified as having "vasculitic"or "eosinophilic"EGPA. At present, ANCA status cannot guide treatment decisions, that is,whether cyclophosphamide, rituximab, ormepolizumab should be added to conventional glucocorticoid treatment. In EGPA, monitoring of ANCA is only useful when MPO-ANCA was tested positive at disease onset. </p>}},
author = {{Moiseev, Sergey and Bossuyt, Xavier and Arimura, Yoshihiro and Blockmans, Daniel and Csernok, Elena and Damoiseaux, Jan and Emmi, Giacomo and Flores-Suarez, Luis Felipe and Hellmich, Bernhard and Jayne, David and Charles Jennette, J. and Little, Mark A. and Mohammad, Aladdin J. and Moosig, Frank and Novikov, Pavel and Pagnoux, Christian and Radice, Antonella and Sada, Ken Ei and Segelmark, Marten and Shoenfeld, Yehuda and Sinico, Renato A. and Specks, Ulrich and Terrier, Benjamin and Tzioufas, Athanasios G. and Vaglio, Augusto and Zhao, Ming Hui and Tervaert, Jan Willem Cohen}},
issn = {{1073-449X}},
keywords = {{ANCA; Consensus; Eosinophilic granulomatosis with polyangiitis; Vasculitis}},
language = {{eng}},
number = {{10}},
pages = {{1360--1372}},
publisher = {{American Thoracic Society}},
series = {{American Journal of Respiratory and Critical Care Medicine}},
title = {{International consensus on antineutrophil cytoplasm antibodies testing in eosinophilic granulomatosis with polyangiitis}},
url = {{http://dx.doi.org/10.1164/rccm.202005-1628SO}},
doi = {{10.1164/rccm.202005-1628SO}},
volume = {{202}},
year = {{2020}},
}