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Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - A histopathological assessment

Haglund, Mattias LU and Englund, Elisabet LU (2002) In Dementia and Geriatric Cognitive Disorders 14(3). p.161-166
Abstract
To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The ratio of amyloid-positive to amyloid-negative vessels in the leptomeninges of the frontal pole from each patient was calculated subsequent to microscopical examination, and the severity of WML was graded according to previously published criteria. In AD cases without a significant component of vascular dementia, the level of CAA was found to correlate with the degree of WML diagnosed and graded by neuropathology. Neither age... (More)
To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The ratio of amyloid-positive to amyloid-negative vessels in the leptomeninges of the frontal pole from each patient was calculated subsequent to microscopical examination, and the severity of WML was graded according to previously published criteria. In AD cases without a significant component of vascular dementia, the level of CAA was found to correlate with the degree of WML diagnosed and graded by neuropathology. Neither age nor severity of AE correlated significantly with WML. There may be several reasons for the conflicting results of this study vis-a-vis earlier investigations; the roles played by different methods of staining, CAA quantitation and patient subgroup selection are also discussed. Copyright (C)2002 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
meningeal vessels, Alzheimer's disease, amyloid load, quantitation, histopathology
in
Dementia and Geriatric Cognitive Disorders
volume
14
issue
3
pages
161 - 166
publisher
Karger
external identifiers
  • wos:000178246700008
  • pmid:12218260
  • scopus:0036355286
ISSN
1420-8008
DOI
10.1159/000063606
language
English
LU publication?
yes
id
a037d79e-545d-4bc8-8e8e-41b509874e4d (old id 327659)
date added to LUP
2007-08-22 15:48:09
date last changed
2017-11-26 03:22:42
@article{a037d79e-545d-4bc8-8e8e-41b509874e4d,
  abstract     = {To test the hypothesis that the cerebral amyloid angiopathy (CAA) of Alzheimer's disease (AD) is quantitatively associated with white matter lesions (WML), the brains of 63 demented patients exhibiting varying degrees of Alzheimer encephalopathy (AE) were examined, along with those of 10 nondemented control cases. The ratio of amyloid-positive to amyloid-negative vessels in the leptomeninges of the frontal pole from each patient was calculated subsequent to microscopical examination, and the severity of WML was graded according to previously published criteria. In AD cases without a significant component of vascular dementia, the level of CAA was found to correlate with the degree of WML diagnosed and graded by neuropathology. Neither age nor severity of AE correlated significantly with WML. There may be several reasons for the conflicting results of this study vis-a-vis earlier investigations; the roles played by different methods of staining, CAA quantitation and patient subgroup selection are also discussed. Copyright (C)2002 S. Karger AG, Basel.},
  author       = {Haglund, Mattias and Englund, Elisabet},
  issn         = {1420-8008},
  keyword      = {meningeal vessels,Alzheimer's disease,amyloid load,quantitation,histopathology},
  language     = {eng},
  number       = {3},
  pages        = {161--166},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - A histopathological assessment},
  url          = {http://dx.doi.org/10.1159/000063606},
  volume       = {14},
  year         = {2002},
}