Does the oral steroid treatment of patients with nasal polyposis cause osteopenia or osteoporosis?
(2019) In Clinical Otolaryngology 44(6). p.1011-1016- Abstract
Objectives: We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate whether the treatment of this patient group is in accordance with the EPOS recommendations. Design, settings and participants: Adult patients with a diagnosis of CRSwNP, and a history of at least two courses of oral corticosteroids (OCS) during the last year, were consecutively included in this study at five centres. Main outcome measures: The BMD of the patients was measured by Dual-energy X-ray absorptiometry (DXA), which is the only technology for classifying BMD according to the criteria established by WHO. Results: A total of 51... (More)
Objectives: We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate whether the treatment of this patient group is in accordance with the EPOS recommendations. Design, settings and participants: Adult patients with a diagnosis of CRSwNP, and a history of at least two courses of oral corticosteroids (OCS) during the last year, were consecutively included in this study at five centres. Main outcome measures: The BMD of the patients was measured by Dual-energy X-ray absorptiometry (DXA), which is the only technology for classifying BMD according to the criteria established by WHO. Results: A total of 51 patients, with an average number of 7 years with OCS treatment, were enrolled. During the last 12 months, the mean number of OCS courses was 2.76, and the total mean intake was 891 mg of Prednisone equivalents. According to the T-scores, 17 patients were measured to have ≤−1 SD T-score lumbar spine, which is considered to be osteopenia, and five patients had <−2.5 SD T-score, considered as osteoporosis. However, when taking age and gender into account and analysing the Z-scores, only 2 patients had a reduced density of the spine and none in the hip, which is no difference compared to a matched Swedish population. Conclusions: This prospective study shows that 2-3 moderate courses of OCS annually may be used without high risk of causing osteopenia/osteoporosis in patients with CRSwNP.
(Less)
- author
- Sahlstrand-Johnson, Pernilla LU ; Holmström, Mats and Ehnhage, Anders
- publishing date
- 2019-09-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bone density, chronic rhinosinusitis, corticosteroids, dual-energy X-ray absorptiometry, DXA, osteopenia, osteoporosis
- in
- Clinical Otolaryngology
- volume
- 44
- issue
- 6
- pages
- 1011 - 1016
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85074611617
- pmid:31529761
- ISSN
- 1749-4478
- DOI
- 10.1111/coa.13431
- language
- English
- LU publication?
- no
- id
- 327d0875-4add-443c-867f-1517b61a5e6a
- date added to LUP
- 2019-11-22 13:40:47
- date last changed
- 2024-05-29 04:16:03
@article{327d0875-4add-443c-867f-1517b61a5e6a,
abstract = {{<p>Objectives: We aimed to investigate the bone mineral density (BMD) in a group of Swedish patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with or without asthma, as well as to evaluate whether the treatment of this patient group is in accordance with the EPOS recommendations. Design, settings and participants: Adult patients with a diagnosis of CRSwNP, and a history of at least two courses of oral corticosteroids (OCS) during the last year, were consecutively included in this study at five centres. Main outcome measures: The BMD of the patients was measured by Dual-energy X-ray absorptiometry (DXA), which is the only technology for classifying BMD according to the criteria established by WHO. Results: A total of 51 patients, with an average number of 7 years with OCS treatment, were enrolled. During the last 12 months, the mean number of OCS courses was 2.76, and the total mean intake was 891 mg of Prednisone equivalents. According to the T-scores, 17 patients were measured to have ≤−1 SD T-score lumbar spine, which is considered to be osteopenia, and five patients had <−2.5 SD T-score, considered as osteoporosis. However, when taking age and gender into account and analysing the Z-scores, only 2 patients had a reduced density of the spine and none in the hip, which is no difference compared to a matched Swedish population. Conclusions: This prospective study shows that 2-3 moderate courses of OCS annually may be used without high risk of causing osteopenia/osteoporosis in patients with CRSwNP.</p>}},
author = {{Sahlstrand-Johnson, Pernilla and Holmström, Mats and Ehnhage, Anders}},
issn = {{1749-4478}},
keywords = {{bone density; chronic rhinosinusitis; corticosteroids; dual-energy X-ray absorptiometry; DXA; osteopenia; osteoporosis}},
language = {{eng}},
month = {{09}},
number = {{6}},
pages = {{1011--1016}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Otolaryngology}},
title = {{Does the oral steroid treatment of patients with nasal polyposis cause osteopenia or osteoporosis?}},
url = {{http://dx.doi.org/10.1111/coa.13431}},
doi = {{10.1111/coa.13431}},
volume = {{44}},
year = {{2019}},
}