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Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition

Ros, Martine M.; Bueno-de-Mesquita, H. Bas; Kampman, Ellen; Buchner, Frederike L.; Aben, Katja K. H.; Egevad, Lars; Overvad, Kim; Tjonneland, Anne; Roswall, Nina and Clavel-Chapelon, Francoise, et al. (2012) In European Journal of Cancer 48(17). p.3267-3277
Abstract
Background: Many epidemiological studies have examined fruit and vegetable consumption in relation to the risk of urothelial cell carcinoma (UCC) of the bladder, but results are inconsistent. The association between fruit and vegetable consumption and UCC risk may vary by bladder tumour aggressiveness. Therefore, we examined the relation between fruit and vegetable consumption and the risk of aggressive and non-aggressive UCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After 8.9 years of follow-up, 947 UCC were diagnosed among 468,656 EPIC participants. Of these, 421 could be classified as aggressive UCC and 433 as non-aggressive UCC cases. At recruitment, fruit and vegetable consumption was... (More)
Background: Many epidemiological studies have examined fruit and vegetable consumption in relation to the risk of urothelial cell carcinoma (UCC) of the bladder, but results are inconsistent. The association between fruit and vegetable consumption and UCC risk may vary by bladder tumour aggressiveness. Therefore, we examined the relation between fruit and vegetable consumption and the risk of aggressive and non-aggressive UCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After 8.9 years of follow-up, 947 UCC were diagnosed among 468,656 EPIC participants. Of these, 421 could be classified as aggressive UCC and 433 as non-aggressive UCC cases. At recruitment, fruit and vegetable consumption was assessed by validated dietary questionnaires. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for smoking status, duration and intensity of smoking, and energy intake. Results: Total consumption of fruits and vegetables was not associated with aggressive UCC nor with non-aggressive UCC. A 25 g/day increase in leafy vegetables and grapes consumption was associated with a reduced risk of non-aggressive UCC (hazard ratio (HR) 0.88; 95% confidence interval (CI) 0.78-1.00 and HR 0.87; 95% CI 0.77-0.98, respectively), while the intake of root vegetables was inversely associated with risk of aggressive UCC (HR 0.87; 95% CI 0.77-0.98). Conclusion: Our study did not confirm a protective effect of total fruit and/or vegetable consumption on aggressive or non-aggressive UCC. High consumption of certain types of vegetables and of fruits may reduce the risk of aggressive or non-aggressive UCC; however chance findings cannot be excluded. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
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keywords
Urothelial cell carcinomas, Bladder cancer, Aggressive, Non-aggressive, Fruit, Vegetables, EPIC, Cohort
in
European Journal of Cancer
volume
48
issue
17
pages
3267 - 3277
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000310569400017
  • scopus:84868206825
ISSN
1879-0852
DOI
10.1016/j.ejca.2012.05.026
language
English
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yes
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286c6739-cd21-48c9-add8-160375f8d1f9 (old id 3283524)
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2013-01-07 09:41:14
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2017-04-09 03:17:26
@article{286c6739-cd21-48c9-add8-160375f8d1f9,
  abstract     = {Background: Many epidemiological studies have examined fruit and vegetable consumption in relation to the risk of urothelial cell carcinoma (UCC) of the bladder, but results are inconsistent. The association between fruit and vegetable consumption and UCC risk may vary by bladder tumour aggressiveness. Therefore, we examined the relation between fruit and vegetable consumption and the risk of aggressive and non-aggressive UCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After 8.9 years of follow-up, 947 UCC were diagnosed among 468,656 EPIC participants. Of these, 421 could be classified as aggressive UCC and 433 as non-aggressive UCC cases. At recruitment, fruit and vegetable consumption was assessed by validated dietary questionnaires. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for smoking status, duration and intensity of smoking, and energy intake. Results: Total consumption of fruits and vegetables was not associated with aggressive UCC nor with non-aggressive UCC. A 25 g/day increase in leafy vegetables and grapes consumption was associated with a reduced risk of non-aggressive UCC (hazard ratio (HR) 0.88; 95% confidence interval (CI) 0.78-1.00 and HR 0.87; 95% CI 0.77-0.98, respectively), while the intake of root vegetables was inversely associated with risk of aggressive UCC (HR 0.87; 95% CI 0.77-0.98). Conclusion: Our study did not confirm a protective effect of total fruit and/or vegetable consumption on aggressive or non-aggressive UCC. High consumption of certain types of vegetables and of fruits may reduce the risk of aggressive or non-aggressive UCC; however chance findings cannot be excluded. (C) 2012 Elsevier Ltd. All rights reserved.},
  author       = {Ros, Martine M. and Bueno-de-Mesquita, H. Bas and Kampman, Ellen and Buchner, Frederike L. and Aben, Katja K. H. and Egevad, Lars and Overvad, Kim and Tjonneland, Anne and Roswall, Nina and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie Christine and Morois, Sophie and Kaaks, Rudolf and Teucher, Birgit and Weikert, Steffen and von Ruesten, Anne and Trichopoulou, Antonia and Naska, Androniki and Benetou, Vassiliki and Saieva, Calogero and Pala, Valeria and Ricceri, Fulvio and Tumino, Rosario and Mattiello, Amalia and Peeters, Petra H. M. and van Gils, Carla H. and Gram, Inger T. and Engeset, Dagrun and Chirlaque, Maria-Dolores and Ardanazx, Eva and Rodriguez, Laudina and Amanio, Pilar and Gonzalez, Carlos A. and Jose Sanchez, Maria and Ulmert, David and Ernstrom, Roy and Ljungberg, Borje and Allen, Naomi E. and Key, Timothy J. and Khaw, Kee-Tee and Wareham, Nick and Slimani, Nadia and Romieu, Isabelle and Kiemeney, Lambertus A. and Riboli, Elio},
  issn         = {1879-0852},
  keyword      = {Urothelial cell carcinomas,Bladder cancer,Aggressive,Non-aggressive,Fruit,Vegetables,EPIC,Cohort},
  language     = {eng},
  number       = {17},
  pages        = {3267--3277},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1016/j.ejca.2012.05.026},
  volume       = {48},
  year         = {2012},
}