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Marked host specificity and lack of phylogeographic population structure of Campylobacter jejuni in wild birds

Griekspoor, Petra ; Colles, Frances M. ; Mccarthy, Noel D. ; Hansbro, Philip M. ; Ashhurst-Smith, Chris ; Olsen, Bjorn ; Hasselquist, Dennis LU ; Maiden, Martin C. J. and Waldenstrom, Jonas (2013) In Molecular Ecology 22(5). p.1463-1472
Abstract
Zoonotic pathogens often infect several animal species, and gene flow among populations infecting different host species may affect the biological traits of the pathogen including host specificity, transmissibility and virulence. The bacterium Campylobacter jejuni is a widespread zoonotic multihost pathogen, which frequently causes gastroenteritis in humans. Poultry products are important transmission vehicles to humans, but the bacterium is common in other domestic and wild animals, particularly birds, which are a potential infection source. Population genetic studies of C. jejuni have mainly investigated isolates from humans and domestic animals, so to assess C. jejuni population structure more broadly and investigate host adaptation,... (More)
Zoonotic pathogens often infect several animal species, and gene flow among populations infecting different host species may affect the biological traits of the pathogen including host specificity, transmissibility and virulence. The bacterium Campylobacter jejuni is a widespread zoonotic multihost pathogen, which frequently causes gastroenteritis in humans. Poultry products are important transmission vehicles to humans, but the bacterium is common in other domestic and wild animals, particularly birds, which are a potential infection source. Population genetic studies of C. jejuni have mainly investigated isolates from humans and domestic animals, so to assess C. jejuni population structure more broadly and investigate host adaptation, 928 wild bird isolates from Europe and Australia were genotyped by multilocus sequencing and compared to the genotypes recovered from 1366 domestic animal and human isolates. Campylobacter jejuni populations from different wild bird species were distinct from each other and from those from domestic animals and humans, and the host species of wild bird was the major determinant of C. jejuni genotype, while geographic origin was of little importance. By comparison, C. jejuni differentiation was restricted between more phylogenetically diverse farm animals, indicating that domesticated animals may represent a novel niche for C. jejuni and thereby driving the evolution of those bacteria as they exploit this niche. Human disease is dominated by isolates from this novel domesticated animal niche. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
disease emergence, epidemiology, host associations, Zoonotic disease
in
Molecular Ecology
volume
22
issue
5
pages
1463 - 1472
publisher
Wiley-Blackwell
external identifiers
  • wos:000315414700020
  • scopus:84874405060
  • pmid:23356487
ISSN
0962-1083
DOI
10.1111/mec.12144
project
Centre for Animal Movement Research
language
English
LU publication?
yes
id
32867175-c637-43b1-9253-3856e17f8572 (old id 3670106)
date added to LUP
2016-04-01 10:07:00
date last changed
2020-01-07 01:40:58
@article{32867175-c637-43b1-9253-3856e17f8572,
  abstract     = {Zoonotic pathogens often infect several animal species, and gene flow among populations infecting different host species may affect the biological traits of the pathogen including host specificity, transmissibility and virulence. The bacterium Campylobacter jejuni is a widespread zoonotic multihost pathogen, which frequently causes gastroenteritis in humans. Poultry products are important transmission vehicles to humans, but the bacterium is common in other domestic and wild animals, particularly birds, which are a potential infection source. Population genetic studies of C. jejuni have mainly investigated isolates from humans and domestic animals, so to assess C. jejuni population structure more broadly and investigate host adaptation, 928 wild bird isolates from Europe and Australia were genotyped by multilocus sequencing and compared to the genotypes recovered from 1366 domestic animal and human isolates. Campylobacter jejuni populations from different wild bird species were distinct from each other and from those from domestic animals and humans, and the host species of wild bird was the major determinant of C. jejuni genotype, while geographic origin was of little importance. By comparison, C. jejuni differentiation was restricted between more phylogenetically diverse farm animals, indicating that domesticated animals may represent a novel niche for C. jejuni and thereby driving the evolution of those bacteria as they exploit this niche. Human disease is dominated by isolates from this novel domesticated animal niche.},
  author       = {Griekspoor, Petra and Colles, Frances M. and Mccarthy, Noel D. and Hansbro, Philip M. and Ashhurst-Smith, Chris and Olsen, Bjorn and Hasselquist, Dennis and Maiden, Martin C. J. and Waldenstrom, Jonas},
  issn         = {0962-1083},
  language     = {eng},
  number       = {5},
  pages        = {1463--1472},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Ecology},
  title        = {Marked host specificity and lack of phylogeographic population structure of Campylobacter jejuni in wild birds},
  url          = {http://dx.doi.org/10.1111/mec.12144},
  doi          = {10.1111/mec.12144},
  volume       = {22},
  year         = {2013},
}