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A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients

Belsito, D.; Bickers, D.; Bruze, Magnus LU ; Calow, P.; Dagli, M. L.; Fryer, A. D.; Greim, H.; Miyachi, Y.; Saurat, J. H. and Sipes, I. G. (2012) In Food and Chemical Toxicology 50. p.269-313
Abstract
The aryl alkyl alcohol simple acid ester derivatives (AAASAE) group of fragrance ingredients was critically evaluated for safety following a complete literature search of the pertinent data. For high end users, calculated maximum skin exposures vary widely from 0.01% to 4.17%. AAASAE exhibit a common route of primary metabolism by carboxylesterases resulting in the formation of the simple acid and an aryl alkyl alcohol. They have low acute toxicity. No significant toxicity was observed in repeat-dose toxicity tests. There was no evidence of carcinogenicity of benzyl alcohol when it was administered in the feed; gavage studies resulted in pancreatic carcinogenesis due to the corn oil vehicle. The AAASAE are not mutagenic in bacterial... (More)
The aryl alkyl alcohol simple acid ester derivatives (AAASAE) group of fragrance ingredients was critically evaluated for safety following a complete literature search of the pertinent data. For high end users, calculated maximum skin exposures vary widely from 0.01% to 4.17%. AAASAE exhibit a common route of primary metabolism by carboxylesterases resulting in the formation of the simple acid and an aryl alkyl alcohol. They have low acute toxicity. No significant toxicity was observed in repeat-dose toxicity tests. There was no evidence of carcinogenicity of benzyl alcohol when it was administered in the feed; gavage studies resulted in pancreatic carcinogenesis due to the corn oil vehicle. The AAASAE are not mutagenic in bacterial systems or in vitro in mammalian cells, and have little to no in vivo genotoxicity. Reproductive and developmental toxicity data show no indication of adverse effects on reproductive function and NOELs for maternal and developmental toxicity are far in excess of current exposure levels. The AAASAE are generally not irritating or sensitizing at the current levels of exposure. The Panel is of the opinion that there are no safety concerns regarding the AAASAE at the current levels of use and exposure. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Review, Safety, Fragrance ingredients, Aryl alkyl alcohol, Simple acid, ester
in
Food and Chemical Toxicology
volume
50
pages
269 - 313
publisher
Elsevier
external identifiers
  • wos:000309574800033
  • scopus:84865736611
ISSN
0278-6915
DOI
10.1016/j.fct.2012.02.091
language
English
LU publication?
yes
id
f44f95d1-df45-4d82-88ae-a32029a5fe84 (old id 3287796)
date added to LUP
2013-01-07 09:32:46
date last changed
2017-10-01 04:12:58
@article{f44f95d1-df45-4d82-88ae-a32029a5fe84,
  abstract     = {The aryl alkyl alcohol simple acid ester derivatives (AAASAE) group of fragrance ingredients was critically evaluated for safety following a complete literature search of the pertinent data. For high end users, calculated maximum skin exposures vary widely from 0.01% to 4.17%. AAASAE exhibit a common route of primary metabolism by carboxylesterases resulting in the formation of the simple acid and an aryl alkyl alcohol. They have low acute toxicity. No significant toxicity was observed in repeat-dose toxicity tests. There was no evidence of carcinogenicity of benzyl alcohol when it was administered in the feed; gavage studies resulted in pancreatic carcinogenesis due to the corn oil vehicle. The AAASAE are not mutagenic in bacterial systems or in vitro in mammalian cells, and have little to no in vivo genotoxicity. Reproductive and developmental toxicity data show no indication of adverse effects on reproductive function and NOELs for maternal and developmental toxicity are far in excess of current exposure levels. The AAASAE are generally not irritating or sensitizing at the current levels of exposure. The Panel is of the opinion that there are no safety concerns regarding the AAASAE at the current levels of use and exposure. (C) 2012 Elsevier Ltd. All rights reserved.},
  author       = {Belsito, D. and Bickers, D. and Bruze, Magnus and Calow, P. and Dagli, M. L. and Fryer, A. D. and Greim, H. and Miyachi, Y. and Saurat, J. H. and Sipes, I. G.},
  issn         = {0278-6915},
  keyword      = {Review,Safety,Fragrance ingredients,Aryl alkyl alcohol,Simple acid,ester},
  language     = {eng},
  pages        = {269--313},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients},
  url          = {http://dx.doi.org/10.1016/j.fct.2012.02.091},
  volume       = {50},
  year         = {2012},
}