High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer
(2012) In Journal of Ovarian Research 5.- Abstract
- The aim of this study was to assess the clinical value of preoperative blood levels of HE4 as a predictor of overall survival in patients with ovarian cancer and to validate previous data of HE4 and the ROMA algorithm including HE4 and CA125 in discriminating benign and malignant ovarian tumors. Experimental design: The preoperative plasma levels of HE4 and CA125 were analyzed with ELISA in 312 patients with adnexal lesions. Tumors were classified as benign (n= 206), borderline (i.e. low malignant potential tumors) (n= 25), and well (n= 14), moderately (n= 15), and poorly (n= 51) differentiated malignant. Results: In univariate Cox regression analyses high levels (dichotomized at the median) of HE4, CA125, increased age (continuous... (More)
- The aim of this study was to assess the clinical value of preoperative blood levels of HE4 as a predictor of overall survival in patients with ovarian cancer and to validate previous data of HE4 and the ROMA algorithm including HE4 and CA125 in discriminating benign and malignant ovarian tumors. Experimental design: The preoperative plasma levels of HE4 and CA125 were analyzed with ELISA in 312 patients with adnexal lesions. Tumors were classified as benign (n= 206), borderline (i.e. low malignant potential tumors) (n= 25), and well (n= 14), moderately (n= 15), and poorly (n= 51) differentiated malignant. Results: In univariate Cox regression analyses high levels (dichotomized at the median) of HE4, CA125, increased age (continuous variable), advanced-stage of disease 2-4, histological grade 3 and non-optimal tumor debulking at primary surgery were all significantly associated with shorter overall survival. A multivariate Cox regression model including pre-operative available covariates HE4 and CA125 both dichotomized at median in addition to age as continuous variable showed that high levels of HE4 was an independent prognostic marker for worse prognosis HR 2.02 (95% CI 1.1-3.8). In postmenopausal women the ROMA algorithm gave the highest AUC of 0.94 (95% CI, 0.90-0.97) which was higher than the separate markers HE4 AUC 0.91 (95% CI 0.86-0.95) and CA125 AUC 0.91(95% CI 0.87-0.96). Conclusions: High concentration of plasma HE4 is an independent preoperative marker of poor prognosis in patients with ovarian cancer. The algorithm ROMA discriminates in postmenopausal women between malignant and benign tumors with an AUC of 0.94. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3287914
- author
- Kalapotharakos, Grigorios LU ; Asciutto, Christine ; Henic, Emir LU ; Casslén, Bertil LU and Borgfeldt, Christer LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HE4, ROMA, Ovarian neoplasm, Survival analyses, Prognosis
- in
- Journal of Ovarian Research
- volume
- 5
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000310266700001
- scopus:84865071868
- ISSN
- 1757-2215
- DOI
- 10.1186/1757-2215-5-20
- language
- English
- LU publication?
- yes
- id
- e0c83414-4f89-4790-8154-cd0b2985383e (old id 3287914)
- date added to LUP
- 2016-04-01 13:33:41
- date last changed
- 2022-04-21 22:20:26
@article{e0c83414-4f89-4790-8154-cd0b2985383e,
abstract = {{The aim of this study was to assess the clinical value of preoperative blood levels of HE4 as a predictor of overall survival in patients with ovarian cancer and to validate previous data of HE4 and the ROMA algorithm including HE4 and CA125 in discriminating benign and malignant ovarian tumors. Experimental design: The preoperative plasma levels of HE4 and CA125 were analyzed with ELISA in 312 patients with adnexal lesions. Tumors were classified as benign (n= 206), borderline (i.e. low malignant potential tumors) (n= 25), and well (n= 14), moderately (n= 15), and poorly (n= 51) differentiated malignant. Results: In univariate Cox regression analyses high levels (dichotomized at the median) of HE4, CA125, increased age (continuous variable), advanced-stage of disease 2-4, histological grade 3 and non-optimal tumor debulking at primary surgery were all significantly associated with shorter overall survival. A multivariate Cox regression model including pre-operative available covariates HE4 and CA125 both dichotomized at median in addition to age as continuous variable showed that high levels of HE4 was an independent prognostic marker for worse prognosis HR 2.02 (95% CI 1.1-3.8). In postmenopausal women the ROMA algorithm gave the highest AUC of 0.94 (95% CI, 0.90-0.97) which was higher than the separate markers HE4 AUC 0.91 (95% CI 0.86-0.95) and CA125 AUC 0.91(95% CI 0.87-0.96). Conclusions: High concentration of plasma HE4 is an independent preoperative marker of poor prognosis in patients with ovarian cancer. The algorithm ROMA discriminates in postmenopausal women between malignant and benign tumors with an AUC of 0.94.}},
author = {{Kalapotharakos, Grigorios and Asciutto, Christine and Henic, Emir and Casslén, Bertil and Borgfeldt, Christer}},
issn = {{1757-2215}},
keywords = {{HE4; ROMA; Ovarian neoplasm; Survival analyses; Prognosis}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Journal of Ovarian Research}},
title = {{High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer}},
url = {{https://lup.lub.lu.se/search/files/3449553/3460727.pdf}},
doi = {{10.1186/1757-2215-5-20}},
volume = {{5}},
year = {{2012}},
}