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Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma

Löfberg, H LU ; Grubb, A LU orcid ; Davidsson, L ; Kjellander, B ; Strömblad, L G LU ; Tibblin, S and Olsson, S O (1983) In Acta Endocrinologica 104(1). p.69-76
Abstract

gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a molecular weight and electrophoretic mobility characteristic for gamma-trace.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adsorption, Animals, Calcitonin/metabolism, Chlorocebus aethiops, Cystatin C, Cystatins, Electrophoresis, Polyacrylamide Gel, Female, Globulins/metabolism, Growth Hormone/metabolism, Humans, Immune Sera, Immunoelectrophoresis, Immunoenzyme Techniques, Thyroid Gland/cytology, Thyroid Neoplasms/metabolism
in
Acta Endocrinologica
volume
104
issue
1
pages
69 - 76
publisher
Society of the European Journal of Endocrinology
external identifiers
  • scopus:0020572415
  • pmid:6353830
ISSN
0001-5598
DOI
10.1530/acta.0.1040069
language
English
LU publication?
yes
id
328b2d8d-55c4-43e5-8fa1-d38a2c91fc06
date added to LUP
2021-10-25 11:54:58
date last changed
2024-01-12 02:56:09
@article{328b2d8d-55c4-43e5-8fa1-d38a2c91fc06,
  abstract     = {{<p>gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a molecular weight and electrophoretic mobility characteristic for gamma-trace.</p>}},
  author       = {{Löfberg, H and Grubb, A and Davidsson, L and Kjellander, B and Strömblad, L G and Tibblin, S and Olsson, S O}},
  issn         = {{0001-5598}},
  keywords     = {{Adsorption; Animals; Calcitonin/metabolism; Chlorocebus aethiops; Cystatin C; Cystatins; Electrophoresis, Polyacrylamide Gel; Female; Globulins/metabolism; Growth Hormone/metabolism; Humans; Immune Sera; Immunoelectrophoresis; Immunoenzyme Techniques; Thyroid Gland/cytology; Thyroid Neoplasms/metabolism}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{69--76}},
  publisher    = {{Society of the European Journal of Endocrinology}},
  series       = {{Acta Endocrinologica}},
  title        = {{Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma}},
  url          = {{http://dx.doi.org/10.1530/acta.0.1040069}},
  doi          = {{10.1530/acta.0.1040069}},
  volume       = {{104}},
  year         = {{1983}},
}