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Changes in the distribution of hepatic arterial blood flow following TIPS with uncovered stent and stent-graft: An experimental study

Keussen, Inger LU ; Song, HY; Bajc, Marika LU and Cwikiel, Wojciech LU (2002) In CardioVascular and Interventional Radiology 25(4). p.314-317
Abstract
Purpose: To evaluate changes in distribution of hepatic arterial blood flow in the liver following insertion of an uncovered stent and subsequently a stent-graft in the trans-jugular intrahepatic portosystemic shunt (TIPS) channel. Methods: The experiments were performed in eight healthy pigs under general anesthesia. In a pilot study in one pig, scintigraphic evaluation of arterial perfusion to the liver was done before and after inflation of a balloon in the right hepatic vein. In the other pigs, outflow from the right liver vein was checked repeatedly by contrast injection through a percutaneously inserted catheter. The arterial perfusion through the liver was examined by scintigraphy, following selective injection of macro-aggregate of... (More)
Purpose: To evaluate changes in distribution of hepatic arterial blood flow in the liver following insertion of an uncovered stent and subsequently a stent-graft in the trans-jugular intrahepatic portosystemic shunt (TIPS) channel. Methods: The experiments were performed in eight healthy pigs under general anesthesia. In a pilot study in one pig, scintigraphic evaluation of arterial perfusion to the liver was done before and after inflation of a balloon in the right hepatic vein. In the other pigs, outflow from the right liver vein was checked repeatedly by contrast injection through a percutaneously inserted catheter. The arterial perfusion through the liver was examined by scintigraphy, following selective injection of macro-aggregate of Tc-99(m)-labeled human serum albumin Tc-99(m)-HSA) into the hepatic artery. This examination was done before and after creation of a TIPS with an uncovered stent and subsequently after insertion of a covered stent-graft into the cranial portion of the shunt channel. Results: In the pilot study changes in the arterial perfusion to the liver were easily detectable by scintigraphy. One pig died during the procedure and another pig was excluded due to dislodgement of the hepatic artery catheter. The inserted covered stent obstructed venous outflow from part of the right liver lobe. The Tc-99(m)-HSA activity in this part remained unchanged after TIPS creation with an uncovered stent. A reduction in activity was seen after insertion of a stent-graft (p = 0.06). Conclusion: The distribution of the hepatic arterial blood flow is affected by creation of a TIPS with a stent-graft, in the experimental pig model. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
portal hypertension, stent-graft, stent, shunt, scintigraphy
in
CardioVascular and Interventional Radiology
volume
25
issue
4
pages
314 - 317
publisher
Springer
external identifiers
  • wos:000177871000009
  • scopus:0036651801
ISSN
1432-086X
DOI
10.1007/s00270-002-1793-4
language
English
LU publication?
yes
id
6d9806ff-2571-4397-977d-3cb3a5c4b27f (old id 329265)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12042991&dopt=Abstract
date added to LUP
2007-11-07 13:56:31
date last changed
2017-01-01 04:30:57
@article{6d9806ff-2571-4397-977d-3cb3a5c4b27f,
  abstract     = {Purpose: To evaluate changes in distribution of hepatic arterial blood flow in the liver following insertion of an uncovered stent and subsequently a stent-graft in the trans-jugular intrahepatic portosystemic shunt (TIPS) channel. Methods: The experiments were performed in eight healthy pigs under general anesthesia. In a pilot study in one pig, scintigraphic evaluation of arterial perfusion to the liver was done before and after inflation of a balloon in the right hepatic vein. In the other pigs, outflow from the right liver vein was checked repeatedly by contrast injection through a percutaneously inserted catheter. The arterial perfusion through the liver was examined by scintigraphy, following selective injection of macro-aggregate of Tc-99(m)-labeled human serum albumin Tc-99(m)-HSA) into the hepatic artery. This examination was done before and after creation of a TIPS with an uncovered stent and subsequently after insertion of a covered stent-graft into the cranial portion of the shunt channel. Results: In the pilot study changes in the arterial perfusion to the liver were easily detectable by scintigraphy. One pig died during the procedure and another pig was excluded due to dislodgement of the hepatic artery catheter. The inserted covered stent obstructed venous outflow from part of the right liver lobe. The Tc-99(m)-HSA activity in this part remained unchanged after TIPS creation with an uncovered stent. A reduction in activity was seen after insertion of a stent-graft (p = 0.06). Conclusion: The distribution of the hepatic arterial blood flow is affected by creation of a TIPS with a stent-graft, in the experimental pig model.},
  author       = {Keussen, Inger and Song, HY and Bajc, Marika and Cwikiel, Wojciech},
  issn         = {1432-086X},
  keyword      = {portal hypertension,stent-graft,stent,shunt,scintigraphy},
  language     = {eng},
  number       = {4},
  pages        = {314--317},
  publisher    = {Springer},
  series       = {CardioVascular and Interventional Radiology},
  title        = {Changes in the distribution of hepatic arterial blood flow following TIPS with uncovered stent and stent-graft: An experimental study},
  url          = {http://dx.doi.org/10.1007/s00270-002-1793-4},
  volume       = {25},
  year         = {2002},
}