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Serotype distribution of clinical streptococcus pneumoniae isolates before the introduction of the 13-valent pneumococcal conjugate vaccine in Cambodia

Inghammar, Malin LU ; By, Youlet; Farris, Christina; Phe, Thong; Borand, Laurence; Kerleguer, Alexandra; Goyet, Sophie; Saphonn, Vonthanak; Phoeung, Chanleakhena and Vong, Sirenda, et al. (2018) In American Journal of Tropical Medicine and Hygiene 98(3). p.791-796
Abstract

Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates of Streptococcus pneumoniae from clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates. PCV13 serotypes accounted for 60% (95% confidence interval [CI] 52-67)... (More)

Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates of Streptococcus pneumoniae from clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates. PCV13 serotypes accounted for 60% (95% confidence interval [CI] 52-67) of all isolates; 56% (95% CI 48-64) of noninvasive and 77% (95% CI 57-89) of invasive isolates. Antibiotic resistance was more common among PCV13 serotypes. This study of clinical S. pneumoniae isolates supports the potential for high reduction in pneumococcal disease burden and may serve as baseline data for future monitoring of S. pneumoniae serotypes circulation after implementation of PCV13 childhood vaccination in Cambodia.

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published
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American Journal of Tropical Medicine and Hygiene
volume
98
issue
3
pages
791 - 796
publisher
AMER SOC TROP MED & HYGIENE
external identifiers
  • scopus:85043527427
ISSN
0002-9637
DOI
10.4269/ajtmh.17-0692
language
English
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yes
id
32b43d9f-6883-4c7e-97b6-2cd7a667f2ae
date added to LUP
2018-03-23 11:47:56
date last changed
2019-11-05 04:51:19
@article{32b43d9f-6883-4c7e-97b6-2cd7a667f2ae,
  abstract     = {<p>Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates of Streptococcus pneumoniae from clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates. PCV13 serotypes accounted for 60% (95% confidence interval [CI] 52-67) of all isolates; 56% (95% CI 48-64) of noninvasive and 77% (95% CI 57-89) of invasive isolates. Antibiotic resistance was more common among PCV13 serotypes. This study of clinical S. pneumoniae isolates supports the potential for high reduction in pneumococcal disease burden and may serve as baseline data for future monitoring of S. pneumoniae serotypes circulation after implementation of PCV13 childhood vaccination in Cambodia.</p>},
  author       = {Inghammar, Malin and By, Youlet and Farris, Christina and Phe, Thong and Borand, Laurence and Kerleguer, Alexandra and Goyet, Sophie and Saphonn, Vonthanak and Phoeung, Chanleakhena and Vong, Sirenda and Rammaert, Blandine and Mayaud, Charles and Guillard, Bertrand and Yasuda, Chadwick and Kasper, Matthew R. and Ford, Gavin and Newell, Steven W. and An, Ung Sam and Sokhal, Buth and Touch, Sok and Turner, Paul and Jacobs, Jan and Messaoudi, Mélina and Komurian-Pradel, Florence and Tarantola, Arnaud},
  issn         = {0002-9637},
  language     = {eng},
  number       = {3},
  pages        = {791--796},
  publisher    = {AMER SOC TROP MED & HYGIENE},
  series       = {American Journal of Tropical Medicine and Hygiene},
  title        = {Serotype distribution of clinical streptococcus pneumoniae isolates before the introduction of the 13-valent pneumococcal conjugate vaccine in Cambodia},
  url          = {http://dx.doi.org/10.4269/ajtmh.17-0692},
  volume       = {98},
  year         = {2018},
}