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Relevance of GSTM1, GSTT1 and GSTP1 Gene Polymorphism to Breast Cancer Susceptibility in Mizoram Population, Northeast India

Kimi, Lalro ; Ghatak, Souvik LU ; Yadav, Ravi Prakash ; Chhuani, Lalhma ; Lallawmzuali, Doris ; Pautu, Jeremy L and Kumar, Nachimuthu Senthil (2015) In Biochemical Genetics 54. p.41-49
Abstract
The enzymes encoded by glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of wide range of carcinogens that are ubiquitous in the environment. Homozygous deletions of the GSTM1 and GSTT1 genes are commonly found and result in lack of enzyme activity. This study was undertaken to evaluate the association between GSTM1, GSTT1 and GSTP1 gene polymorphism and breast cancer risk in Mizoram population. Odd ratio (OR) and 95% confidence interval (CI) from conditional logistic regression model were used to estimate the association between genetic polymorphism and breast cancer risk. The GSTM1 and GSTT1 null genotypes were associated with an increased risk of breast cancer [OR = 10.80 (95% CI... (More)
The enzymes encoded by glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of wide range of carcinogens that are ubiquitous in the environment. Homozygous deletions of the GSTM1 and GSTT1 genes are commonly found and result in lack of enzyme activity. This study was undertaken to evaluate the association between GSTM1, GSTT1 and GSTP1 gene polymorphism and breast cancer risk in Mizoram population. Odd ratio (OR) and 95% confidence interval (CI) from conditional logistic regression model were used to estimate the association between genetic polymorphism and breast cancer risk. The GSTM1 and GSTT1 null genotypes were associated with an increased risk of breast cancer [OR = 10.80 (95% CI 1.16–100.43)]. The risk of breast cancer associated with the GSTT1 null genotype was observed to be low among postmenopausal women. When considered together, GSTM1 and GSTT1 genotypes were found to be associated with an increased risk of breast cancer. The relationship between GSTM1 and GSTT1 gene deletions and breast cancer risk was substantially altered by consumption of Smoked Meat/Vegetable. In the present study, GSTP1Ile105Val (rs1695) polymorphism was related to breast cancer susceptibility or phenotype. Our data provides evidence for substantially increased risk of breast cancer associated with GSTM1 and/or GSTT1 homozygous gene deletions in Mizoram population. (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
in
Biochemical Genetics
volume
54
pages
41 - 49
publisher
Springer
external identifiers
  • scopus:84955361978
ISSN
1573-4927
DOI
10.1007/s10528-015-9698-5
language
English
LU publication?
no
id
32e3708d-d8dc-4cca-8ec0-9a58fdc9f2d9
date added to LUP
2021-11-09 16:19:34
date last changed
2022-04-11 21:15:50
@article{32e3708d-d8dc-4cca-8ec0-9a58fdc9f2d9,
  abstract     = {{The enzymes encoded by glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are involved in the metabolism of wide range of carcinogens that are ubiquitous in the environment. Homozygous deletions of the GSTM1 and GSTT1 genes are commonly found and result in lack of enzyme activity. This study was undertaken to evaluate the association between GSTM1, GSTT1 and GSTP1 gene polymorphism and breast cancer risk in Mizoram population. Odd ratio (OR) and 95% confidence interval (CI) from conditional logistic regression model were used to estimate the association between genetic polymorphism and breast cancer risk. The GSTM1 and GSTT1 null genotypes were associated with an increased risk of breast cancer [OR = 10.80 (95% CI 1.16–100.43)]. The risk of breast cancer associated with the GSTT1 null genotype was observed to be low among postmenopausal women. When considered together, GSTM1 and GSTT1 genotypes were found to be associated with an increased risk of breast cancer. The relationship between GSTM1 and GSTT1 gene deletions and breast cancer risk was substantially altered by consumption of Smoked Meat/Vegetable. In the present study, GSTP1Ile105Val (rs1695) polymorphism was related to breast cancer susceptibility or phenotype. Our data provides evidence for substantially increased risk of breast cancer associated with GSTM1 and/or GSTT1 homozygous gene deletions in Mizoram population.}},
  author       = {{Kimi, Lalro and Ghatak, Souvik and Yadav, Ravi Prakash and Chhuani, Lalhma and Lallawmzuali, Doris and Pautu, Jeremy L and Kumar, Nachimuthu Senthil}},
  issn         = {{1573-4927}},
  language     = {{eng}},
  pages        = {{41--49}},
  publisher    = {{Springer}},
  series       = {{Biochemical Genetics}},
  title        = {{Relevance of GSTM1, GSTT1 and GSTP1 Gene Polymorphism to Breast Cancer Susceptibility in Mizoram Population, Northeast India}},
  url          = {{http://dx.doi.org/10.1007/s10528-015-9698-5}},
  doi          = {{10.1007/s10528-015-9698-5}},
  volume       = {{54}},
  year         = {{2015}},
}