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Fusion of the FUS and ATF1 genes in a large, deep-seated angiomatoid fibrous histiocytoma

Raddaoui, E; Donner, L and Panagopoulos, Ioannis LU (2002) In Diagnostic Molecular Pathology 11(3). p.157-162
Abstract
We report a case of a large, deep-seated, diagnostically difficult angiomatoid fibrous histiocytoma. The neoplastic cells were positive for vimentin, calponin, CD99, and, focally, for desmin and contained intertwining cytoplasmic processes joined by desmosomelike junctions. Fusion of codon 175 of the FUS gene to codon 110 of the ATF1 gene was detected by reverse transcription-polymerase chain reaction. Because identical fusion of the FUS and ATF1 genes has been recently reported in another case of angiomatoid fibrous histiocytoma, fusion of these genes may be characteristic for at least a subset of these tumors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
molecular biology, ultrastructure, angiomatoid fibrous histiocytoma, immunohistochemistry, FUS gene, ATF1 gene
in
Diagnostic Molecular Pathology
volume
11
issue
3
pages
157 - 162
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:12218455
  • wos:000177638600006
  • scopus:0036707752
ISSN
1052-9551
language
English
LU publication?
yes
id
db6611b4-df07-43fd-958a-51d397ec6c9e (old id 330132)
alternative location
http://www.molecularpathology.com/pt/re/dmp/abstract.00019606-200209000-00006.htm
date added to LUP
2007-11-09 14:04:19
date last changed
2017-08-20 04:21:30
@article{db6611b4-df07-43fd-958a-51d397ec6c9e,
  abstract     = {We report a case of a large, deep-seated, diagnostically difficult angiomatoid fibrous histiocytoma. The neoplastic cells were positive for vimentin, calponin, CD99, and, focally, for desmin and contained intertwining cytoplasmic processes joined by desmosomelike junctions. Fusion of codon 175 of the FUS gene to codon 110 of the ATF1 gene was detected by reverse transcription-polymerase chain reaction. Because identical fusion of the FUS and ATF1 genes has been recently reported in another case of angiomatoid fibrous histiocytoma, fusion of these genes may be characteristic for at least a subset of these tumors.},
  author       = {Raddaoui, E and Donner, L and Panagopoulos, Ioannis},
  issn         = {1052-9551},
  keyword      = {molecular biology,ultrastructure,angiomatoid fibrous histiocytoma,immunohistochemistry,FUS gene,ATF1 gene},
  language     = {eng},
  number       = {3},
  pages        = {157--162},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Diagnostic Molecular Pathology},
  title        = {Fusion of the FUS and ATF1 genes in a large, deep-seated angiomatoid fibrous histiocytoma},
  volume       = {11},
  year         = {2002},
}