Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis
(2002) In Arthritis Research & Therapy 4(5). p.296-301- Abstract
- Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/330186
- author
- Hansson, AS and Holmdahl, Rikard LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- relapsing polychondritis, model, collagen, matrilin, rheumatoid, arthritis
- in
- Arthritis Research & Therapy
- volume
- 4
- issue
- 5
- pages
- 296 - 301
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:12223103
- wos:000177695600008
- scopus:0036024681
- ISSN
- 1465-9913
- DOI
- 10.1186/ar425
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 01af654c-d1df-441a-90cd-22b3d1ba133e (old id 330186)
- date added to LUP
- 2016-04-01 16:31:08
- date last changed
- 2022-03-15 01:06:56
@article{01af654c-d1df-441a-90cd-22b3d1ba133e, abstract = {{Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.}}, author = {{Hansson, AS and Holmdahl, Rikard}}, issn = {{1465-9913}}, keywords = {{relapsing polychondritis; model; collagen; matrilin; rheumatoid; arthritis}}, language = {{eng}}, number = {{5}}, pages = {{296--301}}, publisher = {{BioMed Central (BMC)}}, series = {{Arthritis Research & Therapy}}, title = {{Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis}}, url = {{http://dx.doi.org/10.1186/ar425}}, doi = {{10.1186/ar425}}, volume = {{4}}, year = {{2002}}, }