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Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis

Hansson, AS and Holmdahl, Rikard LU (2002) In Arthritis Research & Therapy 4(5). p.296-301
Abstract
Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
relapsing polychondritis, model, collagen, matrilin, rheumatoid, arthritis
in
Arthritis Research & Therapy
volume
4
issue
5
pages
296 - 301
publisher
BioMed Central
external identifiers
  • pmid:12223103
  • wos:000177695600008
  • scopus:0036024681
ISSN
1465-9913
DOI
10.1186/ar425
language
English
LU publication?
yes
id
01af654c-d1df-441a-90cd-22b3d1ba133e (old id 330186)
date added to LUP
2007-08-23 13:16:36
date last changed
2017-01-01 07:07:33
@article{01af654c-d1df-441a-90cd-22b3d1ba133e,
  abstract     = {Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.},
  author       = {Hansson, AS and Holmdahl, Rikard},
  issn         = {1465-9913},
  keyword      = {relapsing polychondritis,model,collagen,matrilin,rheumatoid,arthritis},
  language     = {eng},
  number       = {5},
  pages        = {296--301},
  publisher    = {BioMed Central},
  series       = {Arthritis Research & Therapy},
  title        = {Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis},
  url          = {http://dx.doi.org/10.1186/ar425},
  volume       = {4},
  year         = {2002},
}