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HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions

Bruford, Elspeth A. ; Antonescu, Cristina R. ; Carroll, Andrew J. ; Chinnaiyan, Arul ; Cree, Ian A. ; Cross, Nicholas C.P. ; Dalgleish, Raymond ; Gale, Robert Peter ; Harrison, Christine J. and Hastings, Rosalind J. , et al. (2021) In Leukemia 35(11). p.3040-3043
Abstract

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
35
issue
11
pages
3040 - 3043
publisher
Nature Publishing Group
external identifiers
  • scopus:85116330776
  • pmid:34615987
ISSN
0887-6924
DOI
10.1038/s41375-021-01436-6
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s).
id
330f14db-fbb9-456b-b31e-c8c302e070ee
date added to LUP
2021-11-01 14:34:43
date last changed
2025-03-09 21:04:08
@misc{330f14db-fbb9-456b-b31e-c8c302e070ee,
  abstract     = {{<p>Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator—a double colon (::)—to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.</p>}},
  author       = {{Bruford, Elspeth A. and Antonescu, Cristina R. and Carroll, Andrew J. and Chinnaiyan, Arul and Cree, Ian A. and Cross, Nicholas C.P. and Dalgleish, Raymond and Gale, Robert Peter and Harrison, Christine J. and Hastings, Rosalind J. and Huret, Jean Loup and Johansson, Bertil and Le Beau, Michelle and Mecucci, Cristina and Mertens, Fredrik and Verhaak, Roel and Mitelman, Felix}},
  issn         = {{0887-6924}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{3040--3043}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Leukemia}},
  title        = {{HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions}},
  url          = {{http://dx.doi.org/10.1038/s41375-021-01436-6}},
  doi          = {{10.1038/s41375-021-01436-6}},
  volume       = {{35}},
  year         = {{2021}},
}