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Effect of pharmaceutically acceptable glycols on the stability of the liquid crystalline gels formed by poloxamer 407 in water

Ivanova, R; Lindman, Björn LU and Alexandridis, Paschalis LU (2002) In Journal of Colloid and Interface Science 252(1). p.226-235
Abstract
The ability of poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) block copolymers (Poloxamers) to form "gels" (lyotropic liquid crystalline structures) in water is of interest to pharmaceutical applications. In such applications the presence of polar organic solvents is often desirable or required. The effect of such solvents on the stability of lyotropic liquid crystalline gels formed by PEO-PPO-PEO block copolymers was assessed by studying the phase behavior and structure in ternary isothermal (25degreesC) systems of pharmaceutical interest consisting of Poloxamer 407 (EO100PO70EO100), water, and one of the following solvents (referred to here collectively as "glycols"): glycerol, propylene glycol, ethanol,... (More)
The ability of poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) block copolymers (Poloxamers) to form "gels" (lyotropic liquid crystalline structures) in water is of interest to pharmaceutical applications. In such applications the presence of polar organic solvents is often desirable or required. The effect of such solvents on the stability of lyotropic liquid crystalline gels formed by PEO-PPO-PEO block copolymers was assessed by studying the phase behavior and structure in ternary isothermal (25degreesC) systems of pharmaceutical interest consisting of Poloxamer 407 (EO100PO70EO100), water, and one of the following solvents (referred to here collectively as "glycols"): glycerol, propylene glycol, ethanol, polyethylene glycol 400, and glucose. Small-angle X-ray scattering was employed to establish the structure of the liquid crystals obtained and to determine their characteristic length scales. The stability range of the liquid crystalline gel phases in the systems studied was found to vary with the glycol type. For example, the micellar cubic structure can accommodate about 0.85:1 parts glucose per part water (in terms of weight) and up to as much as 5.5:1 parts propylene glycol per part water. A correlation between the glycol effects on the stability of the liquid crystalline phases and glycol physiochemical characteristics such as octanol/water partition coefficient or solubility parameter is proposed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gels, glucose, PEG400, ethanol, propylene glycol, glycerol, glycol, poloxamer, pluronic, lyotropic liquids crystals, SAXS
in
Journal of Colloid and Interface Science
volume
252
issue
1
pages
226 - 235
publisher
Elsevier
external identifiers
  • wos:000177481300029
  • scopus:0036386890
ISSN
1095-7103
DOI
10.1006/jcis.2002.8417
language
English
LU publication?
yes
id
53f94c86-41f0-46ab-8b14-7ed098a3efd4 (old id 331011)
date added to LUP
2007-10-23 11:18:33
date last changed
2017-08-06 03:33:53
@article{53f94c86-41f0-46ab-8b14-7ed098a3efd4,
  abstract     = {The ability of poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) block copolymers (Poloxamers) to form "gels" (lyotropic liquid crystalline structures) in water is of interest to pharmaceutical applications. In such applications the presence of polar organic solvents is often desirable or required. The effect of such solvents on the stability of lyotropic liquid crystalline gels formed by PEO-PPO-PEO block copolymers was assessed by studying the phase behavior and structure in ternary isothermal (25degreesC) systems of pharmaceutical interest consisting of Poloxamer 407 (EO100PO70EO100), water, and one of the following solvents (referred to here collectively as "glycols"): glycerol, propylene glycol, ethanol, polyethylene glycol 400, and glucose. Small-angle X-ray scattering was employed to establish the structure of the liquid crystals obtained and to determine their characteristic length scales. The stability range of the liquid crystalline gel phases in the systems studied was found to vary with the glycol type. For example, the micellar cubic structure can accommodate about 0.85:1 parts glucose per part water (in terms of weight) and up to as much as 5.5:1 parts propylene glycol per part water. A correlation between the glycol effects on the stability of the liquid crystalline phases and glycol physiochemical characteristics such as octanol/water partition coefficient or solubility parameter is proposed.},
  author       = {Ivanova, R and Lindman, Björn and Alexandridis, Paschalis},
  issn         = {1095-7103},
  keyword      = {gels,glucose,PEG400,ethanol,propylene glycol,glycerol,glycol,poloxamer,pluronic,lyotropic liquids crystals,SAXS},
  language     = {eng},
  number       = {1},
  pages        = {226--235},
  publisher    = {Elsevier},
  series       = {Journal of Colloid and Interface Science},
  title        = {Effect of pharmaceutically acceptable glycols on the stability of the liquid crystalline gels formed by poloxamer 407 in water},
  url          = {http://dx.doi.org/10.1006/jcis.2002.8417},
  volume       = {252},
  year         = {2002},
}