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Cerebral platelet thromboembolism and thromboxane synthetase inhibition

Fredriksson, Kent ; Rosén, I. LU ; Johansson, B. B. and Wieloch, T. LU (1985) In Stroke 16(5). p.800-805
Abstract

Platelet aggregating sodium arachidonate was slowly infused into the internal carotid artery (1 mg, 100 µl, 1µl/s) of nitrous oxide anesthetized rats. The electroencephalographic activity recorded by a Cerebral Function Monitor from the injected hemisphere was reduced within minutes. The so matose nsory evoked responses to contralateral electrical stimulation of the whisker area were eliminated on the same side in most cases when measured five and fifteen minutes after the infusion. The brain was frozen in situ with liquid nitrogen after fifteen minutes. Regional tissue analysis showed ipsilateral derangement of the cerebral energy state and increased lactate levels. Pretreatment with the platelet antlaggregating thromboxane synthetase... (More)

Platelet aggregating sodium arachidonate was slowly infused into the internal carotid artery (1 mg, 100 µl, 1µl/s) of nitrous oxide anesthetized rats. The electroencephalographic activity recorded by a Cerebral Function Monitor from the injected hemisphere was reduced within minutes. The so matose nsory evoked responses to contralateral electrical stimulation of the whisker area were eliminated on the same side in most cases when measured five and fifteen minutes after the infusion. The brain was frozen in situ with liquid nitrogen after fifteen minutes. Regional tissue analysis showed ipsilateral derangement of the cerebral energy state and increased lactate levels. Pretreatment with the platelet antlaggregating thromboxane synthetase inhibitor OKY-1581 (Sodium-3-4-(3-pyridylmethyl)phenyl-2-methyI-acry-late), 30 mg/kg i.v., fifteen minutes before the sodium arachidonate infusion prevented cerebral energy failure and elimination of the sensory evoked responses.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Stroke
volume
16
issue
5
pages
6 pages
publisher
American Heart Association
external identifiers
  • pmid:2996185
  • scopus:0021934514
ISSN
0039-2499
DOI
10.1161/01.STR.16.5.800
language
English
LU publication?
no
id
3313b001-7be4-4040-b9b0-1d14ca7db96a
date added to LUP
2019-06-13 17:02:38
date last changed
2021-01-03 04:23:59
@article{3313b001-7be4-4040-b9b0-1d14ca7db96a,
  abstract     = {<p>Platelet aggregating sodium arachidonate was slowly infused into the internal carotid artery (1 mg, 100 µl, 1µl/s) of nitrous oxide anesthetized rats. The electroencephalographic activity recorded by a Cerebral Function Monitor from the injected hemisphere was reduced within minutes. The so matose nsory evoked responses to contralateral electrical stimulation of the whisker area were eliminated on the same side in most cases when measured five and fifteen minutes after the infusion. The brain was frozen in situ with liquid nitrogen after fifteen minutes. Regional tissue analysis showed ipsilateral derangement of the cerebral energy state and increased lactate levels. Pretreatment with the platelet antlaggregating thromboxane synthetase inhibitor OKY-1581 (Sodium-3-4-(3-pyridylmethyl)phenyl-2-methyI-acry-late), 30 mg/kg i.v., fifteen minutes before the sodium arachidonate infusion prevented cerebral energy failure and elimination of the sensory evoked responses.</p>},
  author       = {Fredriksson, Kent and Rosén, I. and Johansson, B. B. and Wieloch, T.},
  issn         = {0039-2499},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {800--805},
  publisher    = {American Heart Association},
  series       = {Stroke},
  title        = {Cerebral platelet thromboembolism and thromboxane synthetase inhibition},
  url          = {http://dx.doi.org/10.1161/01.STR.16.5.800},
  doi          = {10.1161/01.STR.16.5.800},
  volume       = {16},
  year         = {1985},
}