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Local changes in cerebral energy metabolism due to brain retraction during routine neurosurgical procedures

Xu, W; Mellergård, Pekka LU ; Ungerstedt, U and Nordström, Carl-Henrik LU (2002) In Acta Neurochirurgica 144(7). p.679-683
Abstract
Patients and Interventions. Tissue damage caused by brain retraction was evaluated utilizing intracerebral microdialysis in six patients operated on subfrontally for pituitary adenoma. The microdialysis probes (membrane length 10 mm, cut-off 20 kDalton) were placed in cerebral cortex beneath the brain retractor and perfused with Ringer solution at 0.3 mul/min. The microdialysis vials were changed at intervals of 30 minutes and analysed for glucose, pyruvate, lactate, glutamate and glycerol. Results. During brain retraction regional intracerebral glucose was within normal range in cortical tissue and the levels of lactate, glutamate, and glycerol as well as the lactate/pyruvate ratio were considerably above normal range. Conclusion. The... (More)
Patients and Interventions. Tissue damage caused by brain retraction was evaluated utilizing intracerebral microdialysis in six patients operated on subfrontally for pituitary adenoma. The microdialysis probes (membrane length 10 mm, cut-off 20 kDalton) were placed in cerebral cortex beneath the brain retractor and perfused with Ringer solution at 0.3 mul/min. The microdialysis vials were changed at intervals of 30 minutes and analysed for glucose, pyruvate, lactate, glutamate and glycerol. Results. During brain retraction regional intracerebral glucose was within normal range in cortical tissue and the levels of lactate, glutamate, and glycerol as well as the lactate/pyruvate ratio were considerably above normal range. Conclusion. The biochemical analysis shows a pronounced incomplete cerebral ischemia due to brain retraction. The increases in glutamate and glycerol indicate tissue damage and degradation of cell membranes. Intracerebral microdialysis may be a valuable tool in the development of optimal techniques for brain retraction during neurosurgical procedures. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebral microdialysis, brain retraction, energy metabolism, ischaemia
in
Acta Neurochirurgica
volume
144
issue
7
pages
679 - 683
publisher
Springer
external identifiers
  • pmid:12181701
  • wos:000177235000007
  • scopus:0036354815
ISSN
0001-6268
DOI
10.1007/s00701-002-0946-1
language
English
LU publication?
yes
id
36316b5e-bead-4a13-b574-734823c9c7cf (old id 332176)
date added to LUP
2007-11-19 12:55:35
date last changed
2017-10-22 04:45:48
@article{36316b5e-bead-4a13-b574-734823c9c7cf,
  abstract     = {Patients and Interventions. Tissue damage caused by brain retraction was evaluated utilizing intracerebral microdialysis in six patients operated on subfrontally for pituitary adenoma. The microdialysis probes (membrane length 10 mm, cut-off 20 kDalton) were placed in cerebral cortex beneath the brain retractor and perfused with Ringer solution at 0.3 mul/min. The microdialysis vials were changed at intervals of 30 minutes and analysed for glucose, pyruvate, lactate, glutamate and glycerol. Results. During brain retraction regional intracerebral glucose was within normal range in cortical tissue and the levels of lactate, glutamate, and glycerol as well as the lactate/pyruvate ratio were considerably above normal range. Conclusion. The biochemical analysis shows a pronounced incomplete cerebral ischemia due to brain retraction. The increases in glutamate and glycerol indicate tissue damage and degradation of cell membranes. Intracerebral microdialysis may be a valuable tool in the development of optimal techniques for brain retraction during neurosurgical procedures.},
  author       = {Xu, W and Mellergård, Pekka and Ungerstedt, U and Nordström, Carl-Henrik},
  issn         = {0001-6268},
  keyword      = {cerebral microdialysis,brain retraction,energy metabolism,ischaemia},
  language     = {eng},
  number       = {7},
  pages        = {679--683},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica},
  title        = {Local changes in cerebral energy metabolism due to brain retraction during routine neurosurgical procedures},
  url          = {http://dx.doi.org/10.1007/s00701-002-0946-1},
  volume       = {144},
  year         = {2002},
}