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Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care

Lourido, J; Ederoth, Per LU ; Sundvall, N; Ungerstedt, U and Nordström, Carl-Henrik LU (2002) In Scandinavian Journal of Clinical & Laboratory Investigation 62(4). p.285-292
Abstract
Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obtained during intensive care in patients with severe injuries. Methods.. The study included 62 patients with severe traumatic brain injuries. All patients received one 30 mm microdialysis catheter (CMA 60, CMA Microdialysis) inserted into periumbilical subcutaneous adipose tissue. The probe was perfused (0.3 mul/min) with a Ringer solution from a... (More)
Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obtained during intensive care in patients with severe injuries. Methods.. The study included 62 patients with severe traumatic brain injuries. All patients received one 30 mm microdialysis catheter (CMA 60, CMA Microdialysis) inserted into periumbilical subcutaneous adipose tissue. The probe was perfused (0.3 mul/min) with a Ringer solution from a microinfusion Pump and analyzed for glucose, lactate, and glycerol. The Study included 2.434 simultaneous analyses of glucose concentration in arterial blood and subcutaneous adipose tissue. Results.' The correlation coefficient for glucose concentration in blood and interstitial fluid was 0.743 for the whole material. The cot-relation was relatively poor for 1-6h after insertion of the probes, During this period. a continuous increase in the Subcutaneous level Of glucose and decreases in lactate and glycerol were noted. Conclusions: The correlation between blood glucose concentration and glucose Concentration in subcutaneous adipose tissue was not as good during intensive care as in normal humans. The poor correlation during the first 6h probably reflects a stress reaction (and possibly local vasoconstriction). Microdialysis of subcutaneous adipose tissue permits frequent bedside analyses of the biochemical composition of the extracellular fluid and may be of value during routine intensive care provided the methodological limitations are recognized. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lactate, glycerol, adipose tissue, glucose, microdialysis
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
62
issue
4
pages
285 - 292
publisher
Informa Healthcare
external identifiers
  • wos:000177144200006
  • pmid:12476927
  • scopus:0036316289
ISSN
1502-7686
DOI
10.1080/003655102760145843
language
English
LU publication?
yes
id
49600f35-c376-4194-b91e-ce652a5d13fc (old id 332202)
date added to LUP
2007-11-23 11:06:12
date last changed
2017-01-01 06:44:40
@article{49600f35-c376-4194-b91e-ce652a5d13fc,
  abstract     = {Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obtained during intensive care in patients with severe injuries. Methods.. The study included 62 patients with severe traumatic brain injuries. All patients received one 30 mm microdialysis catheter (CMA 60, CMA Microdialysis) inserted into periumbilical subcutaneous adipose tissue. The probe was perfused (0.3 mul/min) with a Ringer solution from a microinfusion Pump and analyzed for glucose, lactate, and glycerol. The Study included 2.434 simultaneous analyses of glucose concentration in arterial blood and subcutaneous adipose tissue. Results.' The correlation coefficient for glucose concentration in blood and interstitial fluid was 0.743 for the whole material. The cot-relation was relatively poor for 1-6h after insertion of the probes, During this period. a continuous increase in the Subcutaneous level Of glucose and decreases in lactate and glycerol were noted. Conclusions: The correlation between blood glucose concentration and glucose Concentration in subcutaneous adipose tissue was not as good during intensive care as in normal humans. The poor correlation during the first 6h probably reflects a stress reaction (and possibly local vasoconstriction). Microdialysis of subcutaneous adipose tissue permits frequent bedside analyses of the biochemical composition of the extracellular fluid and may be of value during routine intensive care provided the methodological limitations are recognized.},
  author       = {Lourido, J and Ederoth, Per and Sundvall, N and Ungerstedt, U and Nordström, Carl-Henrik},
  issn         = {1502-7686},
  keyword      = {lactate,glycerol,adipose tissue,glucose,microdialysis},
  language     = {eng},
  number       = {4},
  pages        = {285--292},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care},
  url          = {http://dx.doi.org/10.1080/003655102760145843},
  volume       = {62},
  year         = {2002},
}