Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
(2002) In British Journal of Cancer 86(12). p.1905-1908- Abstract
- The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil... (More)
- The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer. (Less)
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https://lup.lub.lu.se/record/333843
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- metastatic breast cancer, microvessel density, chemotherapy, predictive, factor
- in
- British Journal of Cancer
- volume
- 86
- issue
- 12
- pages
- 1905 - 1908
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000176739800013
- pmid:12085184
- scopus:18544364795
- ISSN
- 1532-1827
- DOI
- 10.1038/sj.bjc.6600325
- language
- English
- LU publication?
- yes
- id
- 6d286cb1-6f08-410e-ae11-9823271793fc (old id 333843)
- date added to LUP
- 2016-04-01 12:10:59
- date last changed
- 2022-03-05 20:05:53
@article{6d286cb1-6f08-410e-ae11-9823271793fc, abstract = {{The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.}}, author = {{Tynninen, O and Sjostrom, J and von Boguslawski, K and Bengtsson, NO and Heikkila, R and Malmström, Per and Ostenstad, B and Wist, E and Valvere, V and Saksela, E and Paavonen, T and Blomqvist, C}}, issn = {{1532-1827}}, keywords = {{metastatic breast cancer; microvessel density; chemotherapy; predictive; factor}}, language = {{eng}}, number = {{12}}, pages = {{1905--1908}}, publisher = {{Nature Publishing Group}}, series = {{British Journal of Cancer}}, title = {{Tumour microvessel density as predictor of chemotherapy response in breast cancer patients}}, url = {{http://dx.doi.org/10.1038/sj.bjc.6600325}}, doi = {{10.1038/sj.bjc.6600325}}, volume = {{86}}, year = {{2002}}, }