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Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

Tynninen, O; Sjostrom, J; von Boguslawski, K; Bengtsson, NO; Heikkila, R; Malmström, Per LU ; Ostenstad, B; Wist, E; Valvere, V and Saksela, E, et al. (2002) In British Journal of Cancer 86(12). p.1905-1908
Abstract
The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil... (More)
The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer. (Less)
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publication status
published
subject
keywords
metastatic breast cancer, microvessel density, chemotherapy, predictive, factor
in
British Journal of Cancer
volume
86
issue
12
pages
1905 - 1908
publisher
Nature Publishing Group
external identifiers
  • wos:000176739800013
  • pmid:12085184
  • scopus:18544364795
ISSN
1532-1827
DOI
10.1038/sj.bjc.6600325
language
English
LU publication?
yes
id
6d286cb1-6f08-410e-ae11-9823271793fc (old id 333843)
date added to LUP
2007-11-16 10:58:53
date last changed
2017-12-10 03:49:08
@article{6d286cb1-6f08-410e-ae11-9823271793fc,
  abstract     = {The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.},
  author       = {Tynninen, O and Sjostrom, J and von Boguslawski, K and Bengtsson, NO and Heikkila, R and Malmström, Per and Ostenstad, B and Wist, E and Valvere, V and Saksela, E and Paavonen, T and Blomqvist, C},
  issn         = {1532-1827},
  keyword      = {metastatic breast cancer,microvessel density,chemotherapy,predictive,factor},
  language     = {eng},
  number       = {12},
  pages        = {1905--1908},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Tumour microvessel density as predictor of chemotherapy response in breast cancer patients},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6600325},
  volume       = {86},
  year         = {2002},
}