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Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats

Kugelberg, FC; Apelqvist, G and Bengtsson, Finn LU (2002) In Pharmacology and Toxicology1987-01-01+01:002004-01-01+01:00 90(6). p.303-310
Abstract
The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and the data were assessed during the first hour as well as during the following 24 hr (the latter for effects on the diurnal rhythm). Rats treated with 100 mg/kg daily exhibited lower peripheral locomotor and rearing activities than the other groups during the first test hour. The ratio between central and peripheral activity increased in a... (More)
The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and the data were assessed during the first hour as well as during the following 24 hr (the latter for effects on the diurnal rhythm). Rats treated with 100 mg/kg daily exhibited lower peripheral locomotor and rearing activities than the other groups during the first test hour. The ratio between central and peripheral activity increased in a dose-dependent non-proportional manner during the first test hour, indicating a general increase in the central arena activity exerted by the rats when treated with citalopram. No major differences were observed between any of the four groups in overall behavioural activities over the 24-hr period. This study indicated that the open-field locomotor and rearing behaviours in normal rats were affected by increasing doses of racemic citalopram, particularly during the first hour of adaptation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmacology and Toxicology1987-01-01+01:002004-01-01+01:00
volume
90
issue
6
pages
303 - 310
publisher
Wiley-Blackwell
external identifiers
  • pmid:12403051
  • wos:000176670700003
  • scopus:0036018536
ISSN
1600-0773
DOI
10.1034/j.1600-0773.2002.900603.x
language
English
LU publication?
yes
id
8ca34d6e-fa16-4e89-a864-fdedd1415ffd (old id 334026)
date added to LUP
2007-11-05 13:00:08
date last changed
2017-11-27 13:09:26
@article{8ca34d6e-fa16-4e89-a864-fdedd1415ffd,
  abstract     = {The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and the data were assessed during the first hour as well as during the following 24 hr (the latter for effects on the diurnal rhythm). Rats treated with 100 mg/kg daily exhibited lower peripheral locomotor and rearing activities than the other groups during the first test hour. The ratio between central and peripheral activity increased in a dose-dependent non-proportional manner during the first test hour, indicating a general increase in the central arena activity exerted by the rats when treated with citalopram. No major differences were observed between any of the four groups in overall behavioural activities over the 24-hr period. This study indicated that the open-field locomotor and rearing behaviours in normal rats were affected by increasing doses of racemic citalopram, particularly during the first hour of adaptation.},
  author       = {Kugelberg, FC and Apelqvist, G and Bengtsson, Finn},
  issn         = {1600-0773},
  language     = {eng},
  number       = {6},
  pages        = {303--310},
  publisher    = {Wiley-Blackwell},
  series       = {Pharmacology and Toxicology1987-01-01+01:002004-01-01+01:00},
  title        = {Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats},
  url          = {http://dx.doi.org/10.1034/j.1600-0773.2002.900603.x},
  volume       = {90},
  year         = {2002},
}