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Characterization of a novel calcium phosphate/sulphate bone cement

Nilsson, M; Fernandez, E; Sarda, S; Lidgren, Lars LU and Planell, JA (2002) In Journal of Biomedical Materials Research 61(4). p.600-607
Abstract
Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder... (More)
Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder (L/P) ratio to obtain a paste was 0.32 mLg(-1). The highest compressive strength (34 MPa) was obtained for the pure alpha-TCP sample. The strength was, in a first approximation, directly correlated to the weight proportions of the powders. X-ray diffraction analysis showed that the relative intensity for CDHA increased linearly, and the one for CSD decreased exponentially, when the amount of alpha-TCP increased. Thus, CSH ceased to transform to CSD when the amount of alpha-TCP increased. Observations in environmental scanning electron microscopy confirmed the X-ray diffraction results. CSH-crystals (100 mum) were embedded in the HA-matrix permitting gradual porosity in the material when resorbed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
porosity, calcium sulphate, bone cement, alpha-tricalcium phosphate., biodegradable material
in
Journal of Biomedical Materials Research
volume
61
issue
4
pages
600 - 607
publisher
John Wiley & Sons
external identifiers
  • wos:000176551800011
  • pmid:12115450
  • scopus:0037104981
ISSN
0021-9304
DOI
10.1002/jbm.10268
language
English
LU publication?
yes
id
2eb5ce5f-5279-4004-a391-ceb049f3b004 (old id 334512)
date added to LUP
2007-11-16 16:35:18
date last changed
2017-12-10 03:39:26
@article{2eb5ce5f-5279-4004-a391-ceb049f3b004,
  abstract     = {Apatitic cements have shown excellent biocompatibility and adequate mechanical properties but have slow resorption in the human body. To assure that new bone tissue grows into the bone defect, a certain porosity is necessary although hard to achieve in injectable cements with suitable mechanical properties. An attempt was made by mixing alpha-tricalcium phosphate (alpha-TCP), calcium sulphate hemihydrate (CSH) and an aqueous solution containing 2.5 wt% of Na2HPO4. The aim was to obtain a material containing two phases: a) one apatitic phase (calcium-deficient hydroxyapatite; CDHA) and b) one resorbable phase (calcium sulphate dihydrate; CSD). alpha-TCP and CSH mixtures were produced at relative intervals of 20 wt%. The liquid-to-powder (L/P) ratio to obtain a paste was 0.32 mLg(-1). The highest compressive strength (34 MPa) was obtained for the pure alpha-TCP sample. The strength was, in a first approximation, directly correlated to the weight proportions of the powders. X-ray diffraction analysis showed that the relative intensity for CDHA increased linearly, and the one for CSD decreased exponentially, when the amount of alpha-TCP increased. Thus, CSH ceased to transform to CSD when the amount of alpha-TCP increased. Observations in environmental scanning electron microscopy confirmed the X-ray diffraction results. CSH-crystals (100 mum) were embedded in the HA-matrix permitting gradual porosity in the material when resorbed.},
  author       = {Nilsson, M and Fernandez, E and Sarda, S and Lidgren, Lars and Planell, JA},
  issn         = {0021-9304},
  keyword      = {porosity,calcium sulphate,bone cement,alpha-tricalcium phosphate.,biodegradable material},
  language     = {eng},
  number       = {4},
  pages        = {600--607},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research},
  title        = {Characterization of a novel calcium phosphate/sulphate bone cement},
  url          = {http://dx.doi.org/10.1002/jbm.10268},
  volume       = {61},
  year         = {2002},
}