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Caudate nucleus dopamine D-2 receptors in vascular dementia

Allard, P; Englund, Elisabet LU and Marcusson, J (2002) In Dementia and Geriatric Cognitive Disorders 14(1). p.22-25
Abstract
Caudate nucleus dopamine (DA) D-2 receptors were studied in patients with vascular dementia (VaD) and in a control group using [H-3]raclopride as a radioligand. There was no significant difference in the number of DA D-2 receptors in the VaD group as compared with controls. The binding affinity was significantly lower in the VaD group. When the VaD group was subdivided into subjects with or without neuroleptic treatment, there were no differences in the numbers of receptors as compared with controls, and the significant differences in binding affinity remained for both VaD subgroups. The present results are. discussed with reference to the previous finding of a reduced density of caudate nucleus DA uptake sites in the same VaD group and to... (More)
Caudate nucleus dopamine (DA) D-2 receptors were studied in patients with vascular dementia (VaD) and in a control group using [H-3]raclopride as a radioligand. There was no significant difference in the number of DA D-2 receptors in the VaD group as compared with controls. The binding affinity was significantly lower in the VaD group. When the VaD group was subdivided into subjects with or without neuroleptic treatment, there were no differences in the numbers of receptors as compared with controls, and the significant differences in binding affinity remained for both VaD subgroups. The present results are. discussed with reference to the previous finding of a reduced density of caudate nucleus DA uptake sites in the same VaD group and to results from studies on DA D-2 receptors in Alzheimer's disease and Parkinson's disease. Copyright (C) 2002 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
caudate, nucleus, vascular dementia, dopamine D-2 receptors, [H-3]raclopride
in
Dementia and Geriatric Cognitive Disorders
volume
14
issue
1
pages
22 - 25
publisher
Karger
external identifiers
  • wos:000176409300004
  • pmid:12053128
  • scopus:0036281088
ISSN
1420-8008
DOI
10.1159/000058329
language
English
LU publication?
yes
id
5afca96f-f0b0-49b9-af84-3f1290e617ee (old id 334569)
date added to LUP
2007-08-06 14:48:19
date last changed
2017-01-01 05:10:49
@article{5afca96f-f0b0-49b9-af84-3f1290e617ee,
  abstract     = {Caudate nucleus dopamine (DA) D-2 receptors were studied in patients with vascular dementia (VaD) and in a control group using [H-3]raclopride as a radioligand. There was no significant difference in the number of DA D-2 receptors in the VaD group as compared with controls. The binding affinity was significantly lower in the VaD group. When the VaD group was subdivided into subjects with or without neuroleptic treatment, there were no differences in the numbers of receptors as compared with controls, and the significant differences in binding affinity remained for both VaD subgroups. The present results are. discussed with reference to the previous finding of a reduced density of caudate nucleus DA uptake sites in the same VaD group and to results from studies on DA D-2 receptors in Alzheimer's disease and Parkinson's disease. Copyright (C) 2002 S. Karger AG, Basel.},
  author       = {Allard, P and Englund, Elisabet and Marcusson, J},
  issn         = {1420-8008},
  keyword      = {caudate,nucleus,vascular dementia,dopamine D-2 receptors,[H-3]raclopride},
  language     = {eng},
  number       = {1},
  pages        = {22--25},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Caudate nucleus dopamine D-2 receptors in vascular dementia},
  url          = {http://dx.doi.org/10.1159/000058329},
  volume       = {14},
  year         = {2002},
}