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Genetic and Environmental Determinants of Early Vascular Ageing (EVA).

Nilsson, Peter LU (2012) In Current Vascular Pharmacology 10(6). p.700-701
Abstract
Cardiovascular disease is multidimensional and new ideas are needed to develop the conventional risk factor paradigm that has been based on the Framingham Heart Study since more than 30 years. Traditional risk factors such as hypertension, smoking, hyperlipidemia and diabetes can only explain about 50% of the distribution of coronary heart disease whereas the inclusion of new risk markers or protective markers may increase the explained proportion up to 80% of myocardial infarction risk according to the INTERHEART study. Still there are substantial differences in cardiovascular risk between regions and populations that are hard to explain. Findings in the former Soviet Union geographical area in Eastern Europe could contribute to new and... (More)
Cardiovascular disease is multidimensional and new ideas are needed to develop the conventional risk factor paradigm that has been based on the Framingham Heart Study since more than 30 years. Traditional risk factors such as hypertension, smoking, hyperlipidemia and diabetes can only explain about 50% of the distribution of coronary heart disease whereas the inclusion of new risk markers or protective markers may increase the explained proportion up to 80% of myocardial infarction risk according to the INTERHEART study. Still there are substantial differences in cardiovascular risk between regions and populations that are hard to explain. Findings in the former Soviet Union geographical area in Eastern Europe could contribute to new and better understanding of cardiovascular risk as a reflection of ageing in general, as populations in these areas not only run a very high cardiovascular risk but also have a shorter mean life expectancy in general. New understanding of the interaction between genes and the environment in prediction of cardiovascular ageing could contribute to the development of more effective preventive strategies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Vascular Pharmacology
volume
10
issue
6
pages
700 - 701
publisher
Bentham Science Publishers
external identifiers
  • wos:000312208300009
  • pmid:23259558
  • scopus:84870222216
ISSN
1570-1611
language
English
LU publication?
yes
id
8058ac61-f4d0-4959-a5f6-7ce575ebce48 (old id 3346968)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23259558?dopt=Abstract
date added to LUP
2013-01-02 13:15:06
date last changed
2017-06-11 04:39:11
@article{8058ac61-f4d0-4959-a5f6-7ce575ebce48,
  abstract     = {Cardiovascular disease is multidimensional and new ideas are needed to develop the conventional risk factor paradigm that has been based on the Framingham Heart Study since more than 30 years. Traditional risk factors such as hypertension, smoking, hyperlipidemia and diabetes can only explain about 50% of the distribution of coronary heart disease whereas the inclusion of new risk markers or protective markers may increase the explained proportion up to 80% of myocardial infarction risk according to the INTERHEART study. Still there are substantial differences in cardiovascular risk between regions and populations that are hard to explain. Findings in the former Soviet Union geographical area in Eastern Europe could contribute to new and better understanding of cardiovascular risk as a reflection of ageing in general, as populations in these areas not only run a very high cardiovascular risk but also have a shorter mean life expectancy in general. New understanding of the interaction between genes and the environment in prediction of cardiovascular ageing could contribute to the development of more effective preventive strategies.},
  author       = {Nilsson, Peter},
  issn         = {1570-1611},
  language     = {eng},
  number       = {6},
  pages        = {700--701},
  publisher    = {Bentham Science Publishers},
  series       = {Current Vascular Pharmacology},
  title        = {Genetic and Environmental Determinants of Early Vascular Ageing (EVA).},
  volume       = {10},
  year         = {2012},
}