Asymmetric Transfer Hydrogenation Coupled with Dynamic Kinetic Resolution in Water: Synthesis of anti-β-Hydroxy-α-amino Acid Derivatives.
(2012) In Organic Letters 14(24). p.6334-6337- Abstract
- The use of asymmetric transfer hydrogenation combined with dynamic kinetic resolution for the synthesis of β-hydroxy-α-(tert-butoxycarbonyl)amino esters in water is described. This procedure provides the desired amino alcohols in good yields, diastereoselectivities, and enantioselectivities. A surfactant is employed to achieve good yields due to the hydrophobic nature of both the catalyst and substrate. The reaction setup is operationally simple, and nondegassed water can be used as the solvent.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347382
- author
- Seashore-Ludlow, Brinton ; Saint-Dizier, François and Somfai, Peter LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organic Letters
- volume
- 14
- issue
- 24
- pages
- 6334 - 6337
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000312564500055
- pmid:23227944
- scopus:84871570629
- pmid:23227944
- ISSN
- 1523-7052
- DOI
- 10.1021/ol303115v
- language
- English
- LU publication?
- yes
- id
- cb1d615d-50d3-4c4c-80d6-744b8a8b5ab4 (old id 3347382)
- date added to LUP
- 2016-04-01 10:39:16
- date last changed
- 2022-04-28 00:05:34
@article{cb1d615d-50d3-4c4c-80d6-744b8a8b5ab4, abstract = {{The use of asymmetric transfer hydrogenation combined with dynamic kinetic resolution for the synthesis of β-hydroxy-α-(tert-butoxycarbonyl)amino esters in water is described. This procedure provides the desired amino alcohols in good yields, diastereoselectivities, and enantioselectivities. A surfactant is employed to achieve good yields due to the hydrophobic nature of both the catalyst and substrate. The reaction setup is operationally simple, and nondegassed water can be used as the solvent.}}, author = {{Seashore-Ludlow, Brinton and Saint-Dizier, François and Somfai, Peter}}, issn = {{1523-7052}}, language = {{eng}}, number = {{24}}, pages = {{6334--6337}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Organic Letters}}, title = {{Asymmetric Transfer Hydrogenation Coupled with Dynamic Kinetic Resolution in Water: Synthesis of anti-β-Hydroxy-α-amino Acid Derivatives.}}, url = {{http://dx.doi.org/10.1021/ol303115v}}, doi = {{10.1021/ol303115v}}, volume = {{14}}, year = {{2012}}, }