Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody.
(2012) In Experimental hematology & oncology 1(1).- Abstract
- Abstract
ABSTRACT:
BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.
FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors.... (More) - Abstract
ABSTRACT:
BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.
FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors. No tumors completely lacked positively stained tumor cells.
CONCLUSIONS: Although it was not possible to demonstrate that the antigen reduction is triggered by the radioimmunotherapy this result stress the importance of considering the risk of reduced antigen expression in metastases after radioimmunotherapy prior to further targeted therapies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347653
- author
- Elgström, Erika LU ; Eriksson, Sophie LU ; Ohlsson, Tomas G LU ; Tennvall, Jan LU and Nilsson, Rune LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental hematology & oncology
- volume
- 1
- issue
- 1
- article number
- 34
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:23210841
- pmid:23210841
- ISSN
- 2162-3619
- DOI
- 10.1186/2162-3619-1-34
- language
- English
- LU publication?
- yes
- id
- a7a0c58e-2b86-4d91-8f90-ef6140e3e175 (old id 3347653)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23210841?dopt=Abstract
- date added to LUP
- 2016-04-01 13:42:15
- date last changed
- 2019-03-13 14:59:39
@article{a7a0c58e-2b86-4d91-8f90-ef6140e3e175, abstract = {{Abstract<br/><br> ABSTRACT:<br/><br> <br/><br> BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.<br/><br> <br/><br> FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors. No tumors completely lacked positively stained tumor cells.<br/><br> <br/><br> CONCLUSIONS: Although it was not possible to demonstrate that the antigen reduction is triggered by the radioimmunotherapy this result stress the importance of considering the risk of reduced antigen expression in metastases after radioimmunotherapy prior to further targeted therapies.}}, author = {{Elgström, Erika and Eriksson, Sophie and Ohlsson, Tomas G and Tennvall, Jan and Nilsson, Rune}}, issn = {{2162-3619}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Experimental hematology & oncology}}, title = {{Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody.}}, url = {{https://lup.lub.lu.se/search/files/3540929/3596087.pdf}}, doi = {{10.1186/2162-3619-1-34}}, volume = {{1}}, year = {{2012}}, }