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Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody.

Elgström, Erika LU ; Eriksson, Sophie LU ; Ohlsson, Tomas G LU ; Tennvall, Jan LU and Nilsson, Rune LU (2012) In Experimental hematology & oncology 1(1).
Abstract
Abstract

ABSTRACT:



BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.



FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors.... (More)
Abstract

ABSTRACT:



BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.



FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors. No tumors completely lacked positively stained tumor cells.



CONCLUSIONS: Although it was not possible to demonstrate that the antigen reduction is triggered by the radioimmunotherapy this result stress the importance of considering the risk of reduced antigen expression in metastases after radioimmunotherapy prior to further targeted therapies. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Experimental hematology & oncology
volume
1
issue
1
publisher
BioMed Central
external identifiers
  • pmid:23210841
ISSN
2162-3619
DOI
10.1186/2162-3619-1-34
language
English
LU publication?
yes
id
a7a0c58e-2b86-4d91-8f90-ef6140e3e175 (old id 3347653)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23210841?dopt=Abstract
date added to LUP
2013-01-02 11:18:22
date last changed
2016-10-21 09:13:06
@article{a7a0c58e-2b86-4d91-8f90-ef6140e3e175,
  abstract     = {Abstract<br/><br>
ABSTRACT:<br/><br>
<br/><br>
BACKGROUND: Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors.<br/><br>
<br/><br>
FINDINGS: 30 of the 35 Brown Norway rats with syngeneic colon carcinoma treated with 400 MBq/kg 177Lu-DOTA-BR96 exhibited consistent complete response of the primary tumor. 13 animals developed metastases that were detected after treatment. The antigen expression was reduced in 17 of 23 metastases detected after radioimmunotherapy compared with untreated tumors. No tumors completely lacked positively stained tumor cells.<br/><br>
<br/><br>
CONCLUSIONS: Although it was not possible to demonstrate that the antigen reduction is triggered by the radioimmunotherapy this result stress the importance of considering the risk of reduced antigen expression in metastases after radioimmunotherapy prior to further targeted therapies.},
  articleno    = {34},
  author       = {Elgström, Erika and Eriksson, Sophie and Ohlsson, Tomas G and Tennvall, Jan and Nilsson, Rune},
  issn         = {2162-3619},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Experimental hematology & oncology},
  title        = {Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody.},
  url          = {http://dx.doi.org/10.1186/2162-3619-1-34},
  volume       = {1},
  year         = {2012},
}