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Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide

Ambrus, Livia LU ; Sunnqvist, Charlotta LU ; Ekman, Rolf; Träskman-Bendz, Lil LU and Westrin, Åsa LU (2016) In Neuropsychobiology 73(4). p.241-248
Abstract

Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality... (More)

Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality dimension Solidity but not with the other personality dimensions or with clinical symptoms. Conclusion: BDNF plays an important role in the regulation of neuroplasticity and neurogenesis in humans. Our results indicate that lower BDNF concentrations are associated with higher levels of impulsiveness and changeability (low scores on the Solidity scale). Furthermore, low plasma BDNF levels may be proposed as a trait marker rather than a state marker for attempted suicide.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain-derived neurotrophic factor, Psychopathology, Suicide
in
Neuropsychobiology
volume
73
issue
4
pages
8 pages
publisher
Karger
external identifiers
  • Scopus:84976313480
  • WOS:000381447700006
ISSN
0302-282X
DOI
10.1159/000446286
language
English
LU publication?
yes
id
33541ac3-4fac-4e36-b4d6-7b6192fa122c
date added to LUP
2016-07-18 09:42:26
date last changed
2017-01-01 08:30:36
@article{33541ac3-4fac-4e36-b4d6-7b6192fa122c,
  abstract     = {<p>Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality dimension Solidity but not with the other personality dimensions or with clinical symptoms. Conclusion: BDNF plays an important role in the regulation of neuroplasticity and neurogenesis in humans. Our results indicate that lower BDNF concentrations are associated with higher levels of impulsiveness and changeability (low scores on the Solidity scale). Furthermore, low plasma BDNF levels may be proposed as a trait marker rather than a state marker for attempted suicide.</p>},
  author       = {Ambrus, Livia and Sunnqvist, Charlotta and Ekman, Rolf and Träskman-Bendz, Lil and Westrin, Åsa},
  issn         = {0302-282X},
  keyword      = {Brain-derived neurotrophic factor,Psychopathology,Suicide},
  language     = {eng},
  month        = {06},
  number       = {4},
  pages        = {241--248},
  publisher    = {Karger},
  series       = {Neuropsychobiology},
  title        = {Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide},
  url          = {http://dx.doi.org/10.1159/000446286},
  volume       = {73},
  year         = {2016},
}