Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide
(2016) In Neuropsychobiology 73(4). p.241-248- Abstract
Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality... (More)
Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality dimension Solidity but not with the other personality dimensions or with clinical symptoms. Conclusion: BDNF plays an important role in the regulation of neuroplasticity and neurogenesis in humans. Our results indicate that lower BDNF concentrations are associated with higher levels of impulsiveness and changeability (low scores on the Solidity scale). Furthermore, low plasma BDNF levels may be proposed as a trait marker rather than a state marker for attempted suicide.
(Less)
- author
- Ambrus, Livia LU ; Sunnqvist, Charlotta LU ; Ekman, Rolf ; Träskman-Bendz, Lil LU and Westrin, Åsa LU
- organization
- publishing date
- 2016-06-22
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain-derived neurotrophic factor, Psychopathology, Suicide
- in
- Neuropsychobiology
- volume
- 73
- issue
- 4
- pages
- 8 pages
- publisher
- Karger
- external identifiers
-
- scopus:84976313480
- pmid:27327436
- wos:000381447700006
- ISSN
- 0302-282X
- DOI
- 10.1159/000446286
- project
- Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.
- language
- English
- LU publication?
- yes
- id
- 33541ac3-4fac-4e36-b4d6-7b6192fa122c
- date added to LUP
- 2016-07-18 09:42:26
- date last changed
- 2024-06-14 11:19:57
@article{33541ac3-4fac-4e36-b4d6-7b6192fa122c,
abstract = {{<p>Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated regarding SB. Methods: Plasma BDNF concentrations were analysed in 61 recent suicide attempters. Clinical symptoms were evaluated using the Comprehensive Psychopathological Rating Scale. Personality dimensions were assessed using the Marke-Nyman Temperament Scale. Results: Plasma BDNF correlated positively and significantly with the personality dimension Solidity but not with the other personality dimensions or with clinical symptoms. Conclusion: BDNF plays an important role in the regulation of neuroplasticity and neurogenesis in humans. Our results indicate that lower BDNF concentrations are associated with higher levels of impulsiveness and changeability (low scores on the Solidity scale). Furthermore, low plasma BDNF levels may be proposed as a trait marker rather than a state marker for attempted suicide.</p>}},
author = {{Ambrus, Livia and Sunnqvist, Charlotta and Ekman, Rolf and Träskman-Bendz, Lil and Westrin, Åsa}},
issn = {{0302-282X}},
keywords = {{Brain-derived neurotrophic factor; Psychopathology; Suicide}},
language = {{eng}},
month = {{06}},
number = {{4}},
pages = {{241--248}},
publisher = {{Karger}},
series = {{Neuropsychobiology}},
title = {{Plasma Brain-Derived Neurotrophic Factor and Psychopathology in Attempted Suicide}},
url = {{http://dx.doi.org/10.1159/000446286}},
doi = {{10.1159/000446286}},
volume = {{73}},
year = {{2016}},
}