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Familial and hormonal risk factors for papillary serous uterine cancer

Elit, L; Pal, T; Goshen, R; Jernström, Helena LU ; Ackerman, I; Fyles, A; Carey, M; Mitchell, M; Aube, J and Narod, SA (2002) In European Journal of Gynaecological Oncology 23(3). p.187-190
Abstract
Objectives: To identify genetic and non-genetic risk factors for papillary serous uterine cancer. Methods: A case-control study was conducted. Case women with papillary serous uterine cancer were compared with two control groups: 1) women with endometrioid uterine cancer and 2) healthy women with no past history of cancer. Cases and controls were matched for age (within two years) and ethnic group. All study subjects completed a questionnaire addressing family history. The cases and healthy controls were assessed for factors associated with estrogen exposure. Results: The risks of breast cancer (RR 1.84, Cl 1.03-331) and of prostate cancer (RR 2.21, CI 0.77-6.37) were higher among the relatives of patients with papillary serous uterine... (More)
Objectives: To identify genetic and non-genetic risk factors for papillary serous uterine cancer. Methods: A case-control study was conducted. Case women with papillary serous uterine cancer were compared with two control groups: 1) women with endometrioid uterine cancer and 2) healthy women with no past history of cancer. Cases and controls were matched for age (within two years) and ethnic group. All study subjects completed a questionnaire addressing family history. The cases and healthy controls were assessed for factors associated with estrogen exposure. Results: The risks of breast cancer (RR 1.84, Cl 1.03-331) and of prostate cancer (RR 2.21, CI 0.77-6.37) were higher among the relatives of patients with papillary serous uterine cancer, than among relatives of those with endometrioid uterine cancer. Other significant risk factors included weight at 18 years (p = 0.04) and the use of estrogen replacement therapy (p = 0.04). Conclusion: Relatives of women with papillary serous cancer of the uterus had an increased risk of breast and prostate cancer. Hormonal exposure also increases the risk for this cancer. These Findings suggest that predisposing genetic factors, possibly related to hormone metabolism, may be common to the three forms of cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hormonal risk factors, papillary serous uterine cancer
in
European Journal of Gynaecological Oncology
volume
23
issue
3
pages
187 - 190
publisher
SOG Canada.
external identifiers
  • wos:000176196700006
  • pmid:12094951
  • scopus:0035986005
ISSN
0392-2936
language
English
LU publication?
yes
id
8e6755eb-259f-4469-bae0-ddd5cfc4459f (old id 335538)
date added to LUP
2007-08-16 16:12:09
date last changed
2017-01-01 07:12:07
@article{8e6755eb-259f-4469-bae0-ddd5cfc4459f,
  abstract     = {Objectives: To identify genetic and non-genetic risk factors for papillary serous uterine cancer. Methods: A case-control study was conducted. Case women with papillary serous uterine cancer were compared with two control groups: 1) women with endometrioid uterine cancer and 2) healthy women with no past history of cancer. Cases and controls were matched for age (within two years) and ethnic group. All study subjects completed a questionnaire addressing family history. The cases and healthy controls were assessed for factors associated with estrogen exposure. Results: The risks of breast cancer (RR 1.84, Cl 1.03-331) and of prostate cancer (RR 2.21, CI 0.77-6.37) were higher among the relatives of patients with papillary serous uterine cancer, than among relatives of those with endometrioid uterine cancer. Other significant risk factors included weight at 18 years (p = 0.04) and the use of estrogen replacement therapy (p = 0.04). Conclusion: Relatives of women with papillary serous cancer of the uterus had an increased risk of breast and prostate cancer. Hormonal exposure also increases the risk for this cancer. These Findings suggest that predisposing genetic factors, possibly related to hormone metabolism, may be common to the three forms of cancer.},
  author       = {Elit, L and Pal, T and Goshen, R and Jernström, Helena and Ackerman, I and Fyles, A and Carey, M and Mitchell, M and Aube, J and Narod, SA},
  issn         = {0392-2936},
  keyword      = {hormonal risk factors,papillary serous uterine cancer},
  language     = {eng},
  number       = {3},
  pages        = {187--190},
  publisher    = {SOG Canada.},
  series       = {European Journal of Gynaecological Oncology},
  title        = {Familial and hormonal risk factors for papillary serous uterine cancer},
  volume       = {23},
  year         = {2002},
}