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Coccidian infection causes oxidative damage in greenfinches

Sepp, T.; Karu, U.; Blount, J. D.; Sild, Elin LU ; Männiste, M. and Hõrak, P. (2012) In PLoS ONE 7.
Abstract
The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic... (More)
The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research. (Less)
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author
publishing date
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Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
7
publisher
Public Library of Science
external identifiers
  • scopus:84866179293
ISSN
1932-6203
DOI
10.1371/journal.pone.0036495
language
English
LU publication?
no
id
2d2bb5e2-fdd5-48b9-98f8-7f747e1cca95 (old id 3359208)
date added to LUP
2013-01-16 13:03:24
date last changed
2017-10-29 04:05:49
@article{2d2bb5e2-fdd5-48b9-98f8-7f747e1cca95,
  abstract     = {The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research.},
  author       = {Sepp, T. and Karu, U. and Blount, J. D. and Sild, Elin and Männiste, M. and Hõrak, P.},
  issn         = {1932-6203},
  language     = {eng},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Coccidian infection causes oxidative damage in greenfinches},
  url          = {http://dx.doi.org/10.1371/journal.pone.0036495},
  volume       = {7},
  year         = {2012},
}