Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound - A European multicenter trial
(2013) In Gynecologic Oncology 128(3). p.449-453- Abstract
- Objective. To compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) in the preoperative assessment of early-stage cervical cancer using pathologic findings as the reference standard. Patients and methods. Prospective multi-center trial enrolling 209 consecutive women with early-stage cervical cancer (FIGO IA2-IIA) scheduled for surgery. The following parameters were assessed on US and MRI and compared to pathology: remaining tumor, size, tumor stromal invasion <2/3 (superficial) or >= 2/3 (deep), and parametrial invasion. Results. Complete data were available for 182 patients. The agreement between US and pathology was excellent for detecting tumors, correctly classifying bulky tumors (>4 cm), and... (More)
- Objective. To compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) in the preoperative assessment of early-stage cervical cancer using pathologic findings as the reference standard. Patients and methods. Prospective multi-center trial enrolling 209 consecutive women with early-stage cervical cancer (FIGO IA2-IIA) scheduled for surgery. The following parameters were assessed on US and MRI and compared to pathology: remaining tumor, size, tumor stromal invasion <2/3 (superficial) or >= 2/3 (deep), and parametrial invasion. Results. Complete data were available for 182 patients. The agreement between US and pathology was excellent for detecting tumors, correctly classifying bulky tumors (>4 cm), and detecting deep stromal invasion (kappa values 0.84, 0.82, and 0.81 respectively); and good for classifying small tumors (<2 cm) and detecting parametrial invasion (kappa values 0.78 and 0.75, respectively). The agreement between MRI and histology was good for classifying tumors as <2 cm, or >4 cm, and detecting deep stromal invasion (kappa values 0.71, 0.76, and 0.77, respectively). It was Moderately accurate in tumor detection, and in assessing parametrial invasion (kappa values 0.52 and 0.45, respectively). The agreement between histology and US was significantly better in assessing residual tumor (p<0.001) and parametrial invasion (p<0.001) than the results obtained by MRI. Imaging methods were not significantly influenced by previous cone biopsy. Conclusion. US and MRI are highly accurate for the preoperative assessment of women with early-stage cervical cancer, although US may be more accurate in detecting residual tumors and assessing parametrial invasion. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Magnetic resonance tomography, Ultrasound, Cervical cancer, Imaging, Staging
- in
- Gynecologic Oncology
- volume
- 128
- issue
- 3
- pages
- 449 - 453
- publisher
- Academic Press
- external identifiers
-
- wos:000315320900008
- scopus:84873714585
- pmid:23022593
- ISSN
- 1095-6859
- DOI
- 10.1016/j.ygyno.2012.09.025
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Department of Obstetrics and Gynaecology (Lund) (013018000), Diagnostic Radiology, (Lund) (013038000), Faculty of Medicine (000022000)
- id
- 3359901c-feb2-4e33-b974-5157781bb9bd (old id 3670031)
- date added to LUP
- 2016-04-01 10:34:50
- date last changed
- 2022-09-15 12:35:42
@article{3359901c-feb2-4e33-b974-5157781bb9bd, abstract = {{Objective. To compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) in the preoperative assessment of early-stage cervical cancer using pathologic findings as the reference standard. Patients and methods. Prospective multi-center trial enrolling 209 consecutive women with early-stage cervical cancer (FIGO IA2-IIA) scheduled for surgery. The following parameters were assessed on US and MRI and compared to pathology: remaining tumor, size, tumor stromal invasion <2/3 (superficial) or >= 2/3 (deep), and parametrial invasion. Results. Complete data were available for 182 patients. The agreement between US and pathology was excellent for detecting tumors, correctly classifying bulky tumors (>4 cm), and detecting deep stromal invasion (kappa values 0.84, 0.82, and 0.81 respectively); and good for classifying small tumors (<2 cm) and detecting parametrial invasion (kappa values 0.78 and 0.75, respectively). The agreement between MRI and histology was good for classifying tumors as <2 cm, or >4 cm, and detecting deep stromal invasion (kappa values 0.71, 0.76, and 0.77, respectively). It was Moderately accurate in tumor detection, and in assessing parametrial invasion (kappa values 0.52 and 0.45, respectively). The agreement between histology and US was significantly better in assessing residual tumor (p<0.001) and parametrial invasion (p<0.001) than the results obtained by MRI. Imaging methods were not significantly influenced by previous cone biopsy. Conclusion. US and MRI are highly accurate for the preoperative assessment of women with early-stage cervical cancer, although US may be more accurate in detecting residual tumors and assessing parametrial invasion. (C) 2012 Elsevier Inc. All rights reserved.}}, author = {{Epstein, Elisabeth and Testa, Antonia and Gaurilcikas, Adrius and Di Legge, Alessia and Ameye, Liveke and Atstupenaite, Vaida and Valentini, Anna Lia and Gui, Benedetta and Wallengren, Nils-Olof and Pudaric, Sonja and Cizauskas, Arvydas and Måsbäck, Anna and Zannoni, Gian Franco and Kannisto, Päivi and Zikan, Michal and Pinkavova, Ivana and Burgetova, Andrea and Dundr, Pavel and Nemejcova, Kristyna and Cibula, David and Fischerova, Daniela}}, issn = {{1095-6859}}, keywords = {{Magnetic resonance tomography; Ultrasound; Cervical cancer; Imaging; Staging}}, language = {{eng}}, number = {{3}}, pages = {{449--453}}, publisher = {{Academic Press}}, series = {{Gynecologic Oncology}}, title = {{Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound - A European multicenter trial}}, url = {{http://dx.doi.org/10.1016/j.ygyno.2012.09.025}}, doi = {{10.1016/j.ygyno.2012.09.025}}, volume = {{128}}, year = {{2013}}, }