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Urinary S100B protein concentrations are increased in intrauterine growth- retarded Newborns

Florio, Pasquale ; Marinoni, Emanuela ; Di Iorio, Romolo ; Bashir, Moataza ; Ciotti, Sabina ; Sacchi, Renata ; Bruschettini, Matteo LU orcid ; Lituania, Mario ; Serra, Giovanni and Michetti, Fabrizio , et al. (2006) In Pediatrics 118(3). p.747-754
Abstract
BACKGROUND. Intrauterine growth retardation is one of the major causes of perinatal mortality and morbidity. To date, there are no reliable methods to detect brain damage in these patients. METHODS. We conducted a case-control study in tertiary NICUs from December 2001 to December 2003 with 42 intrauterine growth retardation infants and 84 controls. Routine laboratory variables, neurologic outcome at 7-day follow-up, ultrasound imaging, and urine concentrations of S100B protein were determined at 5 time points. Urine S100B levels were measured by an immunoluminometric assay at first urination, 24, 48, and 72 hours, and 7 days after birth. Routine laboratory parameters and neurologic patterns were assessed at the same time as urine... (More)
BACKGROUND. Intrauterine growth retardation is one of the major causes of perinatal mortality and morbidity. To date, there are no reliable methods to detect brain damage in these patients. METHODS. We conducted a case-control study in tertiary NICUs from December 2001 to December 2003 with 42 intrauterine growth retardation infants and 84 controls. Routine laboratory variables, neurologic outcome at 7-day follow-up, ultrasound imaging, and urine concentrations of S100B protein were determined at 5 time points. Urine S100B levels were measured by an immunoluminometric assay at first urination, 24, 48, and 72 hours, and 7 days after birth. Routine laboratory parameters and neurologic patterns were assessed at the same time as urine sampling. RESULTS. S100B protein was significantly higher at all of the monitoring time points in urine taken from intrauterine growth retardation newborns than in control infants. When intrauterine growth retardation infants were corrected for the presence of abnormal (group A) or normal (group B) neurologic examination 7 days after birth, S100B was significantly higher at all of the predetermined monitoring time points in group A infants than in group B or controls. At a cutoff of 7.37 multiples of median at first urination, S100B achieved a sensitivity of 95% and a specificity of 99.1% as a single marker for predicting an adverse neurologic outcome. Twenty of 126 patients had neurologic abnormalities, making an overall prevalence of the disease in our population of 15.9% (pretest probability). With respect to the performance of S100B in predicting brain damage, its positive and negative predictive values were 91.0% and 99.0%, respectively. CONCLUSIONS. Increased urine S100B protein levels in intrauterine growth retardation newborns in the first week after birth suggest the presence of brain damage reasonably because of intrauterine hypoxia. Longitudinal S100B protein measurements soon after birth are a useful tool to identify which intrauterine growth retardation infants are at risk of possible neurologic sequelae. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
IUGR, newborn, S100B protein, brain protein, brain damage
in
Pediatrics
volume
118
issue
3
pages
747 - 754
publisher
American Academy of Pediatrics
external identifiers
  • wos:000240959100102
  • scopus:33749067249
ISSN
1098-4275
DOI
10.1542/peds.2005-2875
language
English
LU publication?
no
id
335a85f9-88f0-4995-8327-442256ce427c (old id 7855499)
date added to LUP
2016-04-01 15:26:07
date last changed
2022-04-14 22:08:22
@article{335a85f9-88f0-4995-8327-442256ce427c,
  abstract     = {{BACKGROUND. Intrauterine growth retardation is one of the major causes of perinatal mortality and morbidity. To date, there are no reliable methods to detect brain damage in these patients. METHODS. We conducted a case-control study in tertiary NICUs from December 2001 to December 2003 with 42 intrauterine growth retardation infants and 84 controls. Routine laboratory variables, neurologic outcome at 7-day follow-up, ultrasound imaging, and urine concentrations of S100B protein were determined at 5 time points. Urine S100B levels were measured by an immunoluminometric assay at first urination, 24, 48, and 72 hours, and 7 days after birth. Routine laboratory parameters and neurologic patterns were assessed at the same time as urine sampling. RESULTS. S100B protein was significantly higher at all of the monitoring time points in urine taken from intrauterine growth retardation newborns than in control infants. When intrauterine growth retardation infants were corrected for the presence of abnormal (group A) or normal (group B) neurologic examination 7 days after birth, S100B was significantly higher at all of the predetermined monitoring time points in group A infants than in group B or controls. At a cutoff of 7.37 multiples of median at first urination, S100B achieved a sensitivity of 95% and a specificity of 99.1% as a single marker for predicting an adverse neurologic outcome. Twenty of 126 patients had neurologic abnormalities, making an overall prevalence of the disease in our population of 15.9% (pretest probability). With respect to the performance of S100B in predicting brain damage, its positive and negative predictive values were 91.0% and 99.0%, respectively. CONCLUSIONS. Increased urine S100B protein levels in intrauterine growth retardation newborns in the first week after birth suggest the presence of brain damage reasonably because of intrauterine hypoxia. Longitudinal S100B protein measurements soon after birth are a useful tool to identify which intrauterine growth retardation infants are at risk of possible neurologic sequelae.}},
  author       = {{Florio, Pasquale and Marinoni, Emanuela and Di Iorio, Romolo and Bashir, Moataza and Ciotti, Sabina and Sacchi, Renata and Bruschettini, Matteo and Lituania, Mario and Serra, Giovanni and Michetti, Fabrizio and Petraglia, Felice and Gazzolo, Diego}},
  issn         = {{1098-4275}},
  keywords     = {{IUGR; newborn; S100B protein; brain protein; brain damage}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{747--754}},
  publisher    = {{American Academy of Pediatrics}},
  series       = {{Pediatrics}},
  title        = {{Urinary S100B protein concentrations are increased in intrauterine growth- retarded Newborns}},
  url          = {{http://dx.doi.org/10.1542/peds.2005-2875}},
  doi          = {{10.1542/peds.2005-2875}},
  volume       = {{118}},
  year         = {{2006}},
}