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Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)

Broome, U ; Glaumann, H ; Lindström, Eva LU ; Loof, L ; Almer, S ; Prytz, Hanne LU ; Sandberg-Gertzen, H ; Lindgren, Stefan LU ; Fork, Thomas LU and Jarnerot, G , et al. (2002) In Journal of Hepatology 36(5). p.586-589
Abstract
Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to... (More)
Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cholangiocarcinoma, natural history, ulcerative colitis, liver transplantation
in
Journal of Hepatology
volume
36
issue
5
pages
586 - 589
publisher
Elsevier
external identifiers
  • wos:000176015600002
  • pmid:11983440
  • scopus:0036265139
ISSN
0168-8278
DOI
10.1016/S0168-8278(02)00036-3
language
English
LU publication?
yes
id
4b9bb9e4-fd58-4aca-9dc2-8ff85cb42ec8 (old id 336030)
date added to LUP
2016-04-01 12:05:35
date last changed
2024-02-23 18:31:47
@article{4b9bb9e4-fd58-4aca-9dc2-8ff85cb42ec8,
  abstract     = {{Background/Aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC). Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months. Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC. Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.}},
  author       = {{Broome, U and Glaumann, H and Lindström, Eva and Loof, L and Almer, S and Prytz, Hanne and Sandberg-Gertzen, H and Lindgren, Stefan and Fork, Thomas and Jarnerot, G and Olsson, R}},
  issn         = {{0168-8278}},
  keywords     = {{cholangiocarcinoma; natural history; ulcerative colitis; liver transplantation}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{586--589}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Hepatology}},
  title        = {{Natural history and outcome in 32 Swedish patients with small duct primary sclerosing cholangitis (PSC)}},
  url          = {{http://dx.doi.org/10.1016/S0168-8278(02)00036-3}},
  doi          = {{10.1016/S0168-8278(02)00036-3}},
  volume       = {{36}},
  year         = {{2002}},
}