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Delta(9)-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism

Zygmunt, Peter LU ; Andersson, David LU and Högestätt, Edward LU (2002) In Journal of Neuroscience 22(11). p.4720-4727
Abstract
Although Delta(9)-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown. These neurons participate not only in pain signaling but also in the local response to tissue injury. Here, we show that THC and cannabinol induce a CB1/CB2 cannabinoid receptor-independent release of calcitonin gene-related peptide from capsaicin-sensitive perivascular sensory nerves. Other psychotropic cannabinoids cannot mimic this action. The vanilloid receptor antagonist ruthenium red abolishes the responses to THC and cannabinol. However, the effect of THC on sensory nerves is intact in vanilloid receptor subtype 1 gene knock-out mice. The THC response depends on extracellular calcium but does not involve known... (More)
Although Delta(9)-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown. These neurons participate not only in pain signaling but also in the local response to tissue injury. Here, we show that THC and cannabinol induce a CB1/CB2 cannabinoid receptor-independent release of calcitonin gene-related peptide from capsaicin-sensitive perivascular sensory nerves. Other psychotropic cannabinoids cannot mimic this action. The vanilloid receptor antagonist ruthenium red abolishes the responses to THC and cannabinol. However, the effect of THC on sensory nerves is intact in vanilloid receptor subtype 1 gene knock-out mice. The THC response depends on extracellular calcium but does not involve known voltage-operated calcium channels, glutamate receptors, or protein kinases A and C. These results may indicate the presence of a novel cannabinoid receptor/ion channel in the pain pathway. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
receptors, pain, nociceptors, capsaicin, cannabis, cannabinol, calcitonin gene-related peptide, cannabinoids, sensory, tetrahydrocannabinol
in
Journal of Neuroscience
volume
22
issue
11
pages
4720 - 4727
publisher
Society for Neuroscience
external identifiers
  • pmid:12040079
  • wos:000175900700053
ISSN
1529-2401
language
English
LU publication?
yes
id
49978e05-1942-4b34-ae57-65650a6a1e3b (old id 336236)
alternative location
http://www.jneurosci.org/cgi/content/full/22/11/4720
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12040079&dopt=Abstract
date added to LUP
2007-11-15 08:31:32
date last changed
2016-04-15 19:13:57
@article{49978e05-1942-4b34-ae57-65650a6a1e3b,
  abstract     = {Although Delta(9)-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown. These neurons participate not only in pain signaling but also in the local response to tissue injury. Here, we show that THC and cannabinol induce a CB1/CB2 cannabinoid receptor-independent release of calcitonin gene-related peptide from capsaicin-sensitive perivascular sensory nerves. Other psychotropic cannabinoids cannot mimic this action. The vanilloid receptor antagonist ruthenium red abolishes the responses to THC and cannabinol. However, the effect of THC on sensory nerves is intact in vanilloid receptor subtype 1 gene knock-out mice. The THC response depends on extracellular calcium but does not involve known voltage-operated calcium channels, glutamate receptors, or protein kinases A and C. These results may indicate the presence of a novel cannabinoid receptor/ion channel in the pain pathway.},
  author       = {Zygmunt, Peter and Andersson, David and Högestätt, Edward},
  issn         = {1529-2401},
  keyword      = {receptors,pain,nociceptors,capsaicin,cannabis,cannabinol,calcitonin gene-related peptide,cannabinoids,sensory,tetrahydrocannabinol},
  language     = {eng},
  number       = {11},
  pages        = {4720--4727},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Delta(9)-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism},
  volume       = {22},
  year         = {2002},
}