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Cyclin D3 protein content in human renal cell carcinoma in relation to cyclin D1 and clinico-pathological parameters

Hedberg, Y; Roos, G; Ljungberg, B and Landberg, Göran LU (2002) In Acta Oncologica 41(2). p.175-181
Abstract
Aberrations in the G1/S checkpoint are common in malignancies and are probably important for tumor development. Few G1/S studies have been performed on renal cell carcinoma (RCC) and therefore in this study the cyclin D3 protein content in 80 RCCs and that in 12 corresponding normal kidney cortex tissues are characterized using Western blotting. High cyclin D3 protein content was observed in 16% of the tumors and was significantly associated with aneuploidy, high TNM stage, high nuclear grade, high proliferation and young age. There was no association between tumor cyclin D3 and patient survival. The cyclin D3 overexpression was confirmed by immunohistochemical staining of 72 tumors, showing both nuclear and cytoplasmic localization of... (More)
Aberrations in the G1/S checkpoint are common in malignancies and are probably important for tumor development. Few G1/S studies have been performed on renal cell carcinoma (RCC) and therefore in this study the cyclin D3 protein content in 80 RCCs and that in 12 corresponding normal kidney cortex tissues are characterized using Western blotting. High cyclin D3 protein content was observed in 16% of the tumors and was significantly associated with aneuploidy, high TNM stage, high nuclear grade, high proliferation and young age. There was no association between tumor cyclin D3 and patient survival. The cyclin D3 overexpression was confirmed by immunohistochemical staining of 72 tumors, showing both nuclear and cytoplasmic localization of cyclin D3 in a fraction of the tumors. The cyclin D1 content has earlier been characterized in this tumor material and there was no relation between cyclin D1 and cyclin D3 protein expression. In summary, a fraction of the tumors overexpressed cyclin D3, supporting that various aberrations in the G1/S transition are implicated in RCCs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
41
issue
2
pages
175 - 181
publisher
Taylor & Francis
external identifiers
  • wos:000175951000011
  • pmid:12102163
  • scopus:0036259177
ISSN
1651-226X
DOI
10.1080/028418602753669562
language
English
LU publication?
yes
id
1be9799f-f9b5-4f52-9ff8-972a3e15186e (old id 336364)
date added to LUP
2007-10-15 09:11:25
date last changed
2017-08-06 04:27:28
@article{1be9799f-f9b5-4f52-9ff8-972a3e15186e,
  abstract     = {Aberrations in the G1/S checkpoint are common in malignancies and are probably important for tumor development. Few G1/S studies have been performed on renal cell carcinoma (RCC) and therefore in this study the cyclin D3 protein content in 80 RCCs and that in 12 corresponding normal kidney cortex tissues are characterized using Western blotting. High cyclin D3 protein content was observed in 16% of the tumors and was significantly associated with aneuploidy, high TNM stage, high nuclear grade, high proliferation and young age. There was no association between tumor cyclin D3 and patient survival. The cyclin D3 overexpression was confirmed by immunohistochemical staining of 72 tumors, showing both nuclear and cytoplasmic localization of cyclin D3 in a fraction of the tumors. The cyclin D1 content has earlier been characterized in this tumor material and there was no relation between cyclin D1 and cyclin D3 protein expression. In summary, a fraction of the tumors overexpressed cyclin D3, supporting that various aberrations in the G1/S transition are implicated in RCCs.},
  author       = {Hedberg, Y and Roos, G and Ljungberg, B and Landberg, Göran},
  issn         = {1651-226X},
  language     = {eng},
  number       = {2},
  pages        = {175--181},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Cyclin D3 protein content in human renal cell carcinoma in relation to cyclin D1 and clinico-pathological parameters},
  url          = {http://dx.doi.org/10.1080/028418602753669562},
  volume       = {41},
  year         = {2002},
}