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No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias

Creese, Byron; Ballard, Clive; Aarsland, Dag; Londos, Elisabet LU ; Sharp, Sally and Jones, Emma (2012) In Neuroscience Letters 531(1). p.1-4
Abstract
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A total of 218 individuals, recruited from centres in Norway, Sweden and the UK were included in this study; 121 with clinically or neuropathologically diagnosed DLB/PDD and 97 age-matched, cognitively normal controls. All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer's disease, the Neuropsychiatric Inventory or the Present Behavioural Examination. Severity of... (More)
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A total of 218 individuals, recruited from centres in Norway, Sweden and the UK were included in this study; 121 with clinically or neuropathologically diagnosed DLB/PDD and 97 age-matched, cognitively normal controls. All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer's disease, the Neuropsychiatric Inventory or the Present Behavioural Examination. Severity of cognitive impairment was measured using the Mini Mental State Examination (MMSE). Both controls and participants with dementia were genotyped for rs4680. In contrast to previous findings, analysis by logistic regression failed to find any associations between rs4680 and psychotic symptoms. Larger studies in well characterised cohorts are warranted in order to investigate this relationship further. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COMT, Polymorphism, Dementia with Lewy bodies, Parkinson's disease, dementia, Psychosis
in
Neuroscience Letters
volume
531
issue
1
pages
1 - 4
publisher
Elsevier
external identifiers
  • wos:000312239300001
  • scopus:84869085843
ISSN
0304-3940
DOI
10.1016/j.neulet.2012.09.062
language
English
LU publication?
yes
id
33678198-614e-4eab-a8e1-46fe3c8dddb5 (old id 3368030)
date added to LUP
2013-02-01 06:58:38
date last changed
2017-02-19 03:12:32
@article{33678198-614e-4eab-a8e1-46fe3c8dddb5,
  abstract     = {We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A total of 218 individuals, recruited from centres in Norway, Sweden and the UK were included in this study; 121 with clinically or neuropathologically diagnosed DLB/PDD and 97 age-matched, cognitively normal controls. All participants with dementia underwent serial evaluation of neuropsychiatric symptoms to assess the presence of persistent delusions and hallucinations using the Columbia University Scale for Psychopathology in Alzheimer's disease, the Neuropsychiatric Inventory or the Present Behavioural Examination. Severity of cognitive impairment was measured using the Mini Mental State Examination (MMSE). Both controls and participants with dementia were genotyped for rs4680. In contrast to previous findings, analysis by logistic regression failed to find any associations between rs4680 and psychotic symptoms. Larger studies in well characterised cohorts are warranted in order to investigate this relationship further. (C) 2012 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Creese, Byron and Ballard, Clive and Aarsland, Dag and Londos, Elisabet and Sharp, Sally and Jones, Emma},
  issn         = {0304-3940},
  keyword      = {COMT,Polymorphism,Dementia with Lewy bodies,Parkinson's disease,dementia,Psychosis},
  language     = {eng},
  number       = {1},
  pages        = {1--4},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias},
  url          = {http://dx.doi.org/10.1016/j.neulet.2012.09.062},
  volume       = {531},
  year         = {2012},
}