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Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension

Melander, Olle LU ; Frandsen, E; Groop, Leif LU and Hulthén, Lennart LU (2002) In Hypertension 39(5). p.996-999
Abstract
The aim of the present Study was to investigate whether plasma concentration of proANP(1-30), the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of Salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP(1-30) and urinary urodilatin excretion were determined at baseline, after I week on a low-salt diet (10 nmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy, subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased... (More)
The aim of the present Study was to investigate whether plasma concentration of proANP(1-30), the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of Salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP(1-30) and urinary urodilatin excretion were determined at baseline, after I week on a low-salt diet (10 nmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy, subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased proANP(1-30) (668+/-330 versus 358+/-150 pmol/L P<0.00001) and urodilatin (18.7+/-5.2 versus 16.0+/-8.3 pmol/24 h P<0.05). ProANP(1-30) correlated with salt sensitivity at baseline (r=0.76, P<0.000001). after the low- (r=0.80. P<0.0000001) and high-salt diets (r=0.85, P<0.00000001). The increase proANP(1-30) induced by changing from the low- to the high-salt diet was also directly related to salt sensitivity (r=0.78, P<0.000001). ProANP(1-30) was not related to urinary sodium excretion. Neither urodilatin nor the sodium-induced change in urodilatin correlated with salt sensitivity. However, urodilatin was related to the urinary sodium excretion at baseline (r=0.58, P<0.01) and after the high-salt diet (r=0.62, P<0.001). In conclusion, the close correlations between proANP(1-30) and salt sensitivity suggest that proANP(1-30) may serve as a marker for salt sensitivity and could be useful in identifying subjects who would benefit from dietary salt restriction to prevent development of hypertension. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sodium, dietary, natriuretic peptides, essential, hypertension, genetics, blood pressure
in
Hypertension
volume
39
issue
5
pages
996 - 999
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:12019282
  • wos:000175853300010
  • scopus:0036100038
ISSN
1524-4563
DOI
10.1161/01.HYP.0000017552.91014.2A
language
English
LU publication?
yes
id
3c2e20b0-847b-4903-a7df-5a2dde1c9efd (old id 337241)
date added to LUP
2007-11-16 16:08:33
date last changed
2017-01-01 05:08:44
@article{3c2e20b0-847b-4903-a7df-5a2dde1c9efd,
  abstract     = {The aim of the present Study was to investigate whether plasma concentration of proANP(1-30), the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of Salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP(1-30) and urinary urodilatin excretion were determined at baseline, after I week on a low-salt diet (10 nmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy, subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased proANP(1-30) (668+/-330 versus 358+/-150 pmol/L P&lt;0.00001) and urodilatin (18.7+/-5.2 versus 16.0+/-8.3 pmol/24 h P&lt;0.05). ProANP(1-30) correlated with salt sensitivity at baseline (r=0.76, P&lt;0.000001). after the low- (r=0.80. P&lt;0.0000001) and high-salt diets (r=0.85, P&lt;0.00000001). The increase proANP(1-30) induced by changing from the low- to the high-salt diet was also directly related to salt sensitivity (r=0.78, P&lt;0.000001). ProANP(1-30) was not related to urinary sodium excretion. Neither urodilatin nor the sodium-induced change in urodilatin correlated with salt sensitivity. However, urodilatin was related to the urinary sodium excretion at baseline (r=0.58, P&lt;0.01) and after the high-salt diet (r=0.62, P&lt;0.001). In conclusion, the close correlations between proANP(1-30) and salt sensitivity suggest that proANP(1-30) may serve as a marker for salt sensitivity and could be useful in identifying subjects who would benefit from dietary salt restriction to prevent development of hypertension.},
  author       = {Melander, Olle and Frandsen, E and Groop, Leif and Hulthén, Lennart},
  issn         = {1524-4563},
  keyword      = {sodium,dietary,natriuretic peptides,essential,hypertension,genetics,blood pressure},
  language     = {eng},
  number       = {5},
  pages        = {996--999},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Hypertension},
  title        = {Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension},
  url          = {http://dx.doi.org/10.1161/01.HYP.0000017552.91014.2A},
  volume       = {39},
  year         = {2002},
}